Effect of Chemotherapy on Fusobacterium nucleatum Abundance in Colorectal Cancer Patients: A Study on Relapsing Patients

An intricate relationship exists, and interactions occur between the gut microbiota and colorectal cancer (CRC). Recent studies have indicated that inflammatory reactions stimulated by Fusobacterium nucleatum ( Fn ) lead to the development of CRC. Radical surgery combined with adjuvant chemotherapy...

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Bibliographic Details
Published in:Indian journal of microbiology 2024-12, Vol.64 (4), p.1938-1950
Main Authors: Zuraik, Abdulrahman A., Daboul, Yaman, Awama, M. Ayman, Yazigi, Haitham, Kayasseh, Moh’d Azzam, Georges, Michael
Format: Article
Language:English
Subjects:
Abundance
adjuvants
Biomedical and Life Sciences
Cancer
Chemotherapy
clinical trials
Colon
Colorectal cancer
Colorectal carcinoma
colorectal neoplasms
drug therapy
FadA gene
Fusobacterium nucleatum
Gene amplification
genes
Intestinal microflora
intestinal microorganisms
Life Sciences
Medical Microbiology
Microbiology
Microbiota
Microorganisms
Original Research Article
Patients
Phenols
postoperative care
relapse
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Summary:An intricate relationship exists, and interactions occur between the gut microbiota and colorectal cancer (CRC). Recent studies have indicated that inflammatory reactions stimulated by Fusobacterium nucleatum ( Fn ) lead to the development of CRC. Radical surgery combined with adjuvant chemotherapy is the primary treatment approach for most CRC patients. This study was designed to evaluate the abundance of Fn as part of the gut microbiota in patients with CRC compared to healthy individuals and to assess the effect of the gut microbiota Fn on patients undergoing adjuvant chemotherapy and those experiencing CRC relapse. There were 201 participants, comprising 50 healthy controls and 151 CRC patients. Stool samples were collected from three CRC groups (postoperatively, chemotherapy and relapse), and the fourth was the healthy control group. The amount of Fn in each sample was analyzed using quantitative loop-mediated isothermal amplification-phenol red (QLAMP-PhR), a novel biomolecular method that targets regions encoding the specific Fn FadA gene. Compared with healthy control stool samples, the Fn levels were significantly elevated in all CRC patient groups ( P  
ISSN:0046-8991
0973-7715
DOI:10.1007/s12088-024-01279-6