Serum SIRT6 Levels Are Associated with Frailty in Older Adults

• Published in: The Journal of nutrition, health & aging health & aging, 2023-09, Vol.27 (9), p.719-725
• Main Authors: Zhu, M., Yang, X., Huang, Y., Wang, Z., Xiong, Zhifan
• Format: Article
• Language: English
• Subjects: Age; Aged; Aging; Biomarkers; Blood pressure; blood serum; Body mass index; China; Chronic illnesses; Cross-Sectional Studies; enzyme-linked immunosorbent assay; Frailty; Gastroenterology; Geriatrics; Geriatrics/Gerontology; hospitals; Humans; Inflammation; Medicine; Medicine & Public Health; Metabolism; Metabolites; Neurosciences; Nutrition; Older people; Original Research; Oxidative stress; people; phenotype; Physiology; Primary Care Medicine; Public health; Quality of Life Research; regression analysis; risk; Sirtuins
• ISSN: 1279-7707; 1760-4788; 1760-4788
• DOI: 10.1007/s12603-023-1969-y

Objectives Frailty is one of the major health problems facing aging societies worldwide. We investigated the association between serum SIRT6 and frailty in older adults. Design Cross-sectional analysis of associations of serum SIRT6 and frailty in older people. Setting Enrolled community-dwelling and hospital outpatient clinic adults older than 65 years old in Wuhan City, Hubei Province, China. Participants A total of 540 community-dwelling older adults (age ≥ 65 years) in Wuhan were included in the study. Measures We used Frailty Phenotype criteria for classifying participants based on their frailty status. Serum SIRT6 was measured using an ELISA kit. Results A total of 540 older adults were included in this cross-sectional study. Serum SIRT6 was lower in the slowness group (7.23±1.81 vs 5.89±1.74, p