Effect of hepatitis B virus infection on the nutrient composition of human breast milk: A prospective cohort study

There are limited data regarding the impact of Hepatitis B virus (HBV) infection on the composition of human breast milk, and there is no international consensus on the nutritional management of newborns of HBV-positive mothers. We hypothesised that HBV infection can alter the composition of breast...

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Bibliographic Details
Published in:Food chemistry 2025-02, Vol.465 (Pt 2), p.141947, Article 141947
Main Authors: Zhang, Peizhen, Jian, Huiqi, Li, Chuo, Yao, Lin, He, Tiantian, Tan, Zhangmin, Zhou, Jin, Yin, Yuzhu
Format: Article
Language:English
Subjects:
Adult
Albumin
albumins
breast milk
Cohort Studies
Female
food chemistry
Glucose
hepatitis B
Hepatitis B - metabolism
Hepatitis B virus
Humans
Infant, Newborn
Lactoferrin
Lactoferrin - analysis
Lactoferrin - metabolism
Milk, Human - chemistry
Milk, Human - metabolism
nutrient content
Nutrients - analysis
Nutrients - metabolism
Pregnancy
Pregnancy Complications, Infectious - metabolism
Pregnancy Complications, Infectious - virology
Prospective Studies
regression analysis
Trace elements
Triglycerides
Young Adult
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Summary:There are limited data regarding the impact of Hepatitis B virus (HBV) infection on the composition of human breast milk, and there is no international consensus on the nutritional management of newborns of HBV-positive mothers. We hypothesised that HBV infection can alter the composition of breast milk and that newborns require additional nutritional supplements for healthy growth. We conducted a prospective observational cohort study that recruited 150 pregnant women with HBV infection and matched them with a healthy control group. Multivariate linear regression analysis revealed that glucose and albumin concentrations were increased in the HBV group (av. 4.65 mmol/L and av. 5.66 g/L, respectively), whereas lactoferrin concentrations decreased (av. 537.68 pg/mL). Therefore, additional lactoferrin supplementation may be necessary for newborns delivered to women with HBV infection. [Display omitted] •HBV infection can alter breast milk composition.•HBV infection is associated with increased breast milk glucose and proteins.•HBV infection is associated with decreased lactoferrin.
ISSN:0308-8146
1873-7072
1873-7072
DOI:10.1016/j.foodchem.2024.141947