Dynapenic Abdominal Obesity and Risk of Heart Disease among Middle-Aged and Older Adults: A Prospective Cohort Study

• Published in: The Journal of nutrition, health & aging health & aging, 2023-09, Vol.27 (9), p.752-758
• Main Authors: Wang, X., Jiang, J., Hu, W., Hu, Y., Qin, L.-Q., Hao, Yuantao, Dong, Jia-Yi
• Format: Article
• Language: English
• Subjects: Abdomen; Aging; Cardiovascular disease; Cohort analysis; cohort studies; disease prevention; Geriatrics/Gerontology; Heart; heart diseases; Longitudinal studies; Medicine; Medicine & Public Health; Middle age; muscle strength; Neurosciences; Nutrition; Obesity; Older people; Original Research; Primary Care Medicine; Quality of Life Research; risk; waist circumference
• ISSN: 1279-7707; 1760-4788; 1760-4788
• DOI: 10.1007/s12603-023-1975-0

Objectives The vicious cycle of dynapenia and abdominal obesity may have synergistic detrimental impacts on health. We aim to investigate the prospective association between dynapenic abdominal obesity and the risk of heart disease among middle-aged and older adults. Design A prospective cohort study. Setting English Longitudinal Study of Ageing, 2002–2019. Participants A total of 4734 participants aged 50 years and older were included. Measurements Individuals were divided into non-dynapenia/non-abdominal obesity (ND/NAO), non-dynapenia/abdominal obesity (ND/AO), dynapenia/non-abdominal obesity (D/NAO), and dynapenia/abdominal obesity (D/AO) according to grip strength and waist circumference at baseline. The Cox proportional hazards models were used to obtain the hazard ratios (HRs) of incident heart disease associated with dynapenia and abdominal obesity after adjusting for potential confounding factors. Results During a median follow-up of 9.5 years, 1040 cases of heart disease were recorded. Compared with ND/NAO group, the multivariable HRs were 1.05 (0.92, 1.21) for ND/AO group, 1.31 (0.96, 1.81) for D/NAO group, and 1.39 (1.03, 1.88) for D/AO group. The significant association of D/AO with incident heart disease was detected in women but not in men [HR = 1.55 (1.07, 2.24) and 1.06 (0.60, 1.88), respectively]. Among middle-aged adults, significant associations of D/NAO and D/AO with incident heart disease were observed [HR = 2.46 (1.42, 4.29) and 1.74 (1.02, 2.97), respectively]. Conclusion Both D/NAO and D/AO might increase the risk of developing heart disease, highlighting the importance of dynapenia and obesity early screening for heart disease prevention.