Dietary supplementation and the role of phytochemicals against the Alzheimer's disease: Focus on polyphenolic compounds

• Published in: The journal of prevention of Alzheimer's disease 2025-01, Vol.12 (1), p.100004
• Main Authors: Naik, Rayees Ahmad, Rajpoot, Roshni, Koiri, Raj Kumar, Bhardwaj, Rima, Aldairi, Abdullah F, Johargy, Ayman K, Faidah, Hani, Babalghith, Ahmad O, Hjazi, Ahmed, Alsanie, Walaa F, Alamri, Abdulhakeem S, Alhomrani, Majid, Alsharif, Abdulaziz, Shkodina, Anastasiia, Singh, Sandeep Kumar
• Format: Article
• Language: English
• Subjects: Alzheimer Disease - drug therapy; Alzheimer Disease - prevention & control; Animals; Dietary Supplements; Humans; Oxidative Stress - drug effects; Phytochemicals - administration & dosage; Phytochemicals - pharmacology; Phytochemicals - therapeutic use; Polyphenols - administration & dosage; Polyphenols - pharmacology; Polyphenols - therapeutic use
• ISSN: 2426-0266; 2426-0266
• DOI: 10.1016/j.tjpad.2024.100004

Alzheimer's disease is a complicated, multifaceted, neurodegenerative illness that places an increasing strain on healthcare systems. Due to increasing malfunction and death of nerve cells, the person suffering from Alzheimer's disease (AD) slowly and steadily loses their memories, cognitive functions and even their personality. Although medications may temporarily enhance memory, there are currently no permanent therapies that can halt or cure this irreversible neurodegenerative process. Nonetheless, fast progress in comprehending the cellular and molecular abnormalities responsible for neuronal degeneration has increased confidence in the development of viable prevention and treatments. All FDA-approved anti-AD medications have merely symptomatic effects and cannot cure the illness. This necessitates the pursuit of alternate treatments. Accumulating data shows that systemic neuroinflammation, oxidative stress and associated mitochondrial dysfunction play crucial roles in the etiology of AD and precede its clinical presentation. Therefore, innovative therapeutic approaches targeting these pathophysiological components of Alzheimer's disease are being explored aggressively in the present scenario. Phytochemicals such as resveratrol, curcumin, quercetin, genistein and catechins are prospective therapies owing to their capacity to alter key AD pathogenetic pathways, such as oxidative stress, neuroinflammation, and mitochondrial dysfunction. The use of new phytochemical delivery strategies would certainly provide the possibility to solve several issues with standard anti-AD medicines. In this review, the roles of phytophenolic compound-based treatment strategies for AD are discussed.