The dynamic effects of nutritional status on chemotherapy-related toxicity in patients with non-Hodgkin's lymphoma

• Published in: European journal of clinical nutrition 2025-01
• Main Authors: Zhou, Qian, Yang, HeXiang, Wang, Xinyue, Wang, LiHong, Yan, XueQian, Zhang, BeiRong, Ma, XueHong, Li, GuoHua, Li, JingLin, Zhang, JiaHui, Yan, ZhiHong, Bao, Ni, Li, Chao, Ge, Peng, Liu, Jia, Luo, Xiaoqin
• Format: Article
• Language: English
• ISSN: 0954-3007; 1476-5640; 1476-5640
• DOI: 10.1038/s41430-025-01565-6

Understanding the dynamic changes in nutritional status of patients with non-Hodgkin's lymphoma (NHL) during chemotherapy is crucial, as it significantly impacts chemotherapy-related toxicity and survival outcomes. This multi-center study included newly diagnosed NHL patients. Nutritional status and chemotherapy-related toxic effects were assessed over the first five chemotherapy sessions, with follow-ups conducted every 3 months. Patients were categorized into three groups based on pre-chemotherapy Patient-Generated Subjective Global Assessment (PG-SGA) scores: Group A (0-1), Group B (2-8), and Group C (>9). Repeated-measures ANOVA and Generalized Estimating Equations (GEE) models were used for analysis, with survival outcomes evaluated via Kaplan-Meier and Cox regression. A total of 143 patients (mean age 50.26 ± 15.02 years) completed the study, over a median follow-up of 18.8 months. PG-SGA scores were highest in Group C during chemotherapy (P