Cell-free Tumor DNA: a Promising Technology for Diagnosis, Surveillance and Therapeutic Decision in Urothelial Carcinoma of the Bladder

This narrative review aims to discuss the latest evidence for cell-free tumor DNA (ctDNA) use in bladder cancer, future perspectives and challenges in implementing this technology in clinical practice. Recent papers describe promising findings regarding ctDNA analysis in blood samples and in urine o...

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Bibliographic Details
Published in:Current oncology reports 2025-02
Main Authors: Martinez, Lucas Motta, Ribeiro, Lorena Cristina São Leão, Guidi, Rodrigo Gilles, de Moraes, Caio Mazzonetto Teofilo, Lyra, Catharina Ribeiro, Liebl, Bruno, Guimarães, Vinicius Henrique Almeida, de Lima, Richard Dobrucki, de Almeida, Lucas Schenk, Suartz, Caio Vinicius, Nahas, William Carlos, Ribeiro-Filho, Leopoldo Alves
Format: Article
Language:English
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Summary:This narrative review aims to discuss the latest evidence for cell-free tumor DNA (ctDNA) use in bladder cancer, future perspectives and challenges in implementing this technology in clinical practice. Recent papers describe promising findings regarding ctDNA analysis in blood samples and in urine of bladder cancer patients. This biomarker can be used as a diagnostic tool, in prognostic evaluation and as additional data for treatment indication and surveillance.
ISSN:1523-3790
1534-6269
1534-6269
DOI:10.1007/s11912-025-01648-4