Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Impacts Long-Term Outcomes After Curative-Intent Surgery for Hepatocellular Carcinoma

Curative surgery for hepatocellular carcinoma (HCC) includes liver resection (LR) and orthotopic liver transplantation (OLT). Due to the obesity epidemic, metabolic dysfunction-associated steatotic liver disease (MASLD) is a frequent HCC aetiology that often coincides with increased alcohol consumpt...

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Published in:Alimentary pharmacology & therapeutics 2025-02
Main Authors: Uluk, Deniz, Pein, Justus, Herda, Sophia, Schliephake, Frederik, Schneider, Carolin V, Bitar, Jude, Dreher, Katharina, Eurich, Dennis, Zhang, Ingrid W, Schaffrath, Lukas, Auer, Timo A, Collettini, Federico, Engelmann, Cornelius, Tacke, Frank, Pratschke, Johann, Lurje, Isabella, Lurje, Georg
Format: Article
Language:English
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Summary:Curative surgery for hepatocellular carcinoma (HCC) includes liver resection (LR) and orthotopic liver transplantation (OLT). Due to the obesity epidemic, metabolic dysfunction-associated steatotic liver disease (MASLD) is a frequent HCC aetiology that often coincides with increased alcohol consumption, termed MetALD, or even alcohol-associated liver disease (ALD). Patients undergoing LR or OLT for HCC at Charité-Universitätsmedizin Berlin (2010-2020) were included in this retrospective cohort study investigating disease aetiology, time to recurrence (TTR), overall survival (OS) and CT-based body composition. Out of 579 patients with HCC, 417 underwent LR and 162 OLT. Tumour aetiologies were viral n = 191 (33.0%), MASLD n = 158 (27.3%), MetALD n = 51 (8.8%), ALD n = 68 (11.7%) and other/cryptogenic n = 111 (19.2%). Patients with MASLD and MetALD had more intramuscular (p 
ISSN:0269-2813
1365-2036
1365-2036
DOI:10.1111/apt.70002