Comment on the mechanical properties of the amyloid fibre, poly(ValGlyGlyLeuGly), obtained by a novel AFM methodology

Poly(ValGlyGlyLeuGly) is an elastin-like polypeptide belonging to the glycine-rich sequences of elastin [1]. When suspended in water and deposited on silicon wafers, it self-assembles in amyloid-like fibres. These fibres, and those from similar sequences show a remarkable resistance to bending, tend...

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Bibliographic Details
Published in:Journal of materials science 2008, Vol.43 (1), p.395-397
Main Authors: Flamia, R., Zhdan, P. A., Castle, J. E., Tamburro, A. M.
Format: Article
Language:English
Subjects:
Aminoacid polymers
Applied sciences
Characterization and Evaluation of Materials
Chemistry and Materials Science
Classical Mechanics
Crystallography and Scattering Methods
Exact sciences and technology
Letter
Materials Science
Mechanical properties
Physicochemistry of polymers
Polymer Sciences
Solid Mechanics
Synthetic biopolymers
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Summary:Poly(ValGlyGlyLeuGly) is an elastin-like polypeptide belonging to the glycine-rich sequences of elastin [1]. When suspended in water and deposited on silicon wafers, it self-assembles in amyloid-like fibres. These fibres, and those from similar sequences show a remarkable resistance to bending, tending to remain straight across large fields of view, even at bridging points between fibres [2, 3]. We have now confirmed this apparent axial stiffness by measurement of mechanical properties using atomic force microscopy (AFM).
ISSN:0022-2461
1573-4803
DOI:10.1007/s10853-007-2289-z