Direct Delivery and Submicrometer Patterning of DNA by a Nanofountain Probe

Biomolecular patterning is achieved using a nanofountain probe (NFP) that delivers a liquid solution of DNA through a volcano‐like aperture to a substrate (see figure). Spot features as small as 200 nm in diameter can be routinely made at room temperature over a wide humidity range. Gold nanoparticl...

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2008-01, Vol.20 (2), p.330-334
Main Authors: Kim, K.-H., Sanedrin, R. G., Ho, A. M., Lee, S. W., Moldovan, N., Mirkin, C. A., Espinosa, H. D.
Format: Article
Language:English
Subjects:
Arrays
DNA
Nanopatterning
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Summary:Biomolecular patterning is achieved using a nanofountain probe (NFP) that delivers a liquid solution of DNA through a volcano‐like aperture to a substrate (see figure). Spot features as small as 200 nm in diameter can be routinely made at room temperature over a wide humidity range. Gold nanoparticles functionalized with sequences complementary to the patterned DNA demonstrate that biological activity is retained by the deposited features.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.200701254