Molded Nanowell Electrodes for Site-Selective Single Liposome Arrays

We present a nanowell (NW)‐based biosensing platform for electrochemically detecting biological reactions on the level of single lipid vesicle. The NW geometry of a gently‐sloped vertical wall is found to be optimal for selective deposition of single liposomes without capillary resistances. Also, th...

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2008-01, Vol.20 (1), p.31-36
Main Authors: Kim, P., Lee, B. K., Lee, H. Y., Kawai, T., Suh, K. Y.
Format: Article
Language:English
Subjects:
Biosensors
Molding
Nanopatterning
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Summary:We present a nanowell (NW)‐based biosensing platform for electrochemically detecting biological reactions on the level of single lipid vesicle. The NW geometry of a gently‐sloped vertical wall is found to be optimal for selective deposition of single liposomes without capillary resistances. Also, the use of a hydrophilic, non‐biofouling PEG copolymer is essential to provide distinctively separated FLV arrays without nonspecific adsorption.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.200700570