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Application of Newly Developed Globular-Shaped Granules of β-Tricalcium Phosphate for Bone Substitute
Globular-shaped beta-tricalcium phosphate (β-TCP) granules were synthesized using a unique dropping slurry method and the biological response was analyzed by implantation into the rat femur. Two kinds of globular-shaped β-TCP granules, composed of either rod-shaped particles or conventional non-rod-...
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| Published in: | Key engineering materials 2008-01, Vol.361-363, p.1013-1016 |
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| Main Authors: | , , , , , , |
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| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c374t-a2a2dd07516c436212574f5c45ef40a8a5bb97c26f8b2bf4b0b6a4bd4e8b2a0d3 |
| container_end_page | 1016 |
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| container_title | Key engineering materials |
| container_volume | 361-363 |
| creator | Ioku, Koji Gonda, Yoshinori Kawachi, Giichiro Kurosawa, Hisashi Ikeda, Tohru Okuda, Takatoshi Yonezawa, Ikuho |
| description | Globular-shaped beta-tricalcium phosphate (β-TCP) granules were synthesized using a unique
dropping slurry method and the biological response was analyzed by implantation into the rat femur. Two
kinds of globular-shaped β-TCP granules, composed of either rod-shaped particles or conventional
non-rod-shaped particles were synthesized, implanted into the left femurs of 8-week-old female Wistar rats,
and analyzed histologically. Commercially available β-TCP granules composed of conventional
non-rod-shaped particles were also implanted as a control experiment. Four weeks after the operation,
part of each implant was already resorbed and the resorbed area was replaced by newly formed bone tissue
and bone marrow. Eight weeks after the operation, the resorption and replacement were advanced in each
implant. At 12 weeks after the operation, residual globular-shaped β-TCP granules composed of
rod-shaped particles were resorbed into compact petrotic bone tissue almost completely. The formation of
less compact petrotic bone tissue was observed in specimens implanted with globular-shaped β-TCP
granules composed of conventional non-rod-shaped particles. Commercially available β-TCP granules
composed of conventional non-rod-shaped particles were mostly resorbed into trabecular bone and the
formation of compact petrotic bone tissue was rarely observed. These data suggested that both the unique
spherical shape and microstructure of β-TCP particles affected bone-forming activity after the operation. |
| doi_str_mv | 10.4028/www.scientific.net/KEM.361-363.1013 |
| format | article |
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dropping slurry method and the biological response was analyzed by implantation into the rat femur. Two
kinds of globular-shaped β-TCP granules, composed of either rod-shaped particles or conventional
non-rod-shaped particles were synthesized, implanted into the left femurs of 8-week-old female Wistar rats,
and analyzed histologically. Commercially available β-TCP granules composed of conventional
non-rod-shaped particles were also implanted as a control experiment. Four weeks after the operation,
part of each implant was already resorbed and the resorbed area was replaced by newly formed bone tissue
and bone marrow. Eight weeks after the operation, the resorption and replacement were advanced in each
implant. At 12 weeks after the operation, residual globular-shaped β-TCP granules composed of
rod-shaped particles were resorbed into compact petrotic bone tissue almost completely. The formation of
less compact petrotic bone tissue was observed in specimens implanted with globular-shaped β-TCP
granules composed of conventional non-rod-shaped particles. Commercially available β-TCP granules
composed of conventional non-rod-shaped particles were mostly resorbed into trabecular bone and the
formation of compact petrotic bone tissue was rarely observed. These data suggested that both the unique
spherical shape and microstructure of β-TCP particles affected bone-forming activity after the operation.</description><identifier>ISSN: 1013-9826</identifier><identifier>ISSN: 1662-9795</identifier><identifier>EISSN: 1662-9795</identifier><identifier>DOI: 10.4028/www.scientific.net/KEM.361-363.1013</identifier><language>eng</language><publisher>Trans Tech Publications Ltd</publisher><ispartof>Key engineering materials, 2008-01, Vol.361-363, p.1013-1016</ispartof><rights>2008 Trans Tech Publications Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c374t-a2a2dd07516c436212574f5c45ef40a8a5bb97c26f8b2bf4b0b6a4bd4e8b2a0d3</citedby><cites>FETCH-LOGICAL-c374t-a2a2dd07516c436212574f5c45ef40a8a5bb97c26f8b2bf4b0b6a4bd4e8b2a0d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttps://www.scientific.net/Image/TitleCover/85?width=600</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids></links><search><creatorcontrib>Ioku, Koji</creatorcontrib><creatorcontrib>Gonda, Yoshinori</creatorcontrib><creatorcontrib>Kawachi, Giichiro</creatorcontrib><creatorcontrib>Kurosawa, Hisashi</creatorcontrib><creatorcontrib>Ikeda, Tohru</creatorcontrib><creatorcontrib>Okuda, Takatoshi</creatorcontrib><creatorcontrib>Yonezawa, Ikuho</creatorcontrib><title>Application of Newly Developed Globular-Shaped Granules of β-Tricalcium Phosphate for Bone Substitute</title><title>Key engineering materials</title><description>Globular-shaped beta-tricalcium phosphate (β-TCP) granules were synthesized using a unique
dropping slurry method and the biological response was analyzed by implantation into the rat femur. Two
kinds of globular-shaped β-TCP granules, composed of either rod-shaped particles or conventional
non-rod-shaped particles were synthesized, implanted into the left femurs of 8-week-old female Wistar rats,
and analyzed histologically. Commercially available β-TCP granules composed of conventional
non-rod-shaped particles were also implanted as a control experiment. Four weeks after the operation,
part of each implant was already resorbed and the resorbed area was replaced by newly formed bone tissue
and bone marrow. Eight weeks after the operation, the resorption and replacement were advanced in each
implant. At 12 weeks after the operation, residual globular-shaped β-TCP granules composed of
rod-shaped particles were resorbed into compact petrotic bone tissue almost completely. The formation of
less compact petrotic bone tissue was observed in specimens implanted with globular-shaped β-TCP
granules composed of conventional non-rod-shaped particles. Commercially available β-TCP granules
composed of conventional non-rod-shaped particles were mostly resorbed into trabecular bone and the
formation of compact petrotic bone tissue was rarely observed. These data suggested that both the unique
spherical shape and microstructure of β-TCP particles affected bone-forming activity after the operation.</description><issn>1013-9826</issn><issn>1662-9795</issn><issn>1662-9795</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNqVkE1u2zAQhYUiAZo4vYNW3QSS-SdKXjqu6xZJf4Cka4KkhjANWlRJKkaulYPkTKXrAFlnMZh5gzcPmK8orjGqGSLd_HA41FFbGJI1VtcDpPnt-kdNOa4opzVGmH4oLjDnpFq0i-Ysz3lVLTrCPxaXMe4QorjDzUVhluPorJbJ-qH0pvwJB_dUfoFHcH6Evtw4ryYnQ3W_lf91kMPkIB69L8_VQ8i3TttpX_7e-jhuZYLS-FDe-AHK-0nFZNOU4Ko4N9JF-PTaZ8Wfr-uH1bfq7tfm-2p5V2naslRJIknfo7bBXDPKCSZNy0yjWQOGIdnJRqlFqwk3nSLKMIUUl0z1DLKWqKez4vMpdwz-7wQxib2NGpyTA_gpivx1g1uCs3F1MurgYwxgxBjsXoYngZE4MhaZsXhjLDJjkRmLzDgXFUegOWV9SkkZS0ygt2LnpzDkF9-V8w9XnpJJ</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Ioku, Koji</creator><creator>Gonda, Yoshinori</creator><creator>Kawachi, Giichiro</creator><creator>Kurosawa, Hisashi</creator><creator>Ikeda, Tohru</creator><creator>Okuda, Takatoshi</creator><creator>Yonezawa, Ikuho</creator><general>Trans Tech Publications Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope></search><sort><creationdate>20080101</creationdate><title>Application of Newly Developed Globular-Shaped Granules of β-Tricalcium Phosphate for Bone Substitute</title><author>Ioku, Koji ; Gonda, Yoshinori ; Kawachi, Giichiro ; Kurosawa, Hisashi ; Ikeda, Tohru ; Okuda, Takatoshi ; Yonezawa, Ikuho</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c374t-a2a2dd07516c436212574f5c45ef40a8a5bb97c26f8b2bf4b0b6a4bd4e8b2a0d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ioku, Koji</creatorcontrib><creatorcontrib>Gonda, Yoshinori</creatorcontrib><creatorcontrib>Kawachi, Giichiro</creatorcontrib><creatorcontrib>Kurosawa, Hisashi</creatorcontrib><creatorcontrib>Ikeda, Tohru</creatorcontrib><creatorcontrib>Okuda, Takatoshi</creatorcontrib><creatorcontrib>Yonezawa, Ikuho</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Key engineering materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ioku, Koji</au><au>Gonda, Yoshinori</au><au>Kawachi, Giichiro</au><au>Kurosawa, Hisashi</au><au>Ikeda, Tohru</au><au>Okuda, Takatoshi</au><au>Yonezawa, Ikuho</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Application of Newly Developed Globular-Shaped Granules of β-Tricalcium Phosphate for Bone Substitute</atitle><jtitle>Key engineering materials</jtitle><date>2008-01-01</date><risdate>2008</risdate><volume>361-363</volume><spage>1013</spage><epage>1016</epage><pages>1013-1016</pages><issn>1013-9826</issn><issn>1662-9795</issn><eissn>1662-9795</eissn><abstract>Globular-shaped beta-tricalcium phosphate (β-TCP) granules were synthesized using a unique
dropping slurry method and the biological response was analyzed by implantation into the rat femur. Two
kinds of globular-shaped β-TCP granules, composed of either rod-shaped particles or conventional
non-rod-shaped particles were synthesized, implanted into the left femurs of 8-week-old female Wistar rats,
and analyzed histologically. Commercially available β-TCP granules composed of conventional
non-rod-shaped particles were also implanted as a control experiment. Four weeks after the operation,
part of each implant was already resorbed and the resorbed area was replaced by newly formed bone tissue
and bone marrow. Eight weeks after the operation, the resorption and replacement were advanced in each
implant. At 12 weeks after the operation, residual globular-shaped β-TCP granules composed of
rod-shaped particles were resorbed into compact petrotic bone tissue almost completely. The formation of
less compact petrotic bone tissue was observed in specimens implanted with globular-shaped β-TCP
granules composed of conventional non-rod-shaped particles. Commercially available β-TCP granules
composed of conventional non-rod-shaped particles were mostly resorbed into trabecular bone and the
formation of compact petrotic bone tissue was rarely observed. These data suggested that both the unique
spherical shape and microstructure of β-TCP particles affected bone-forming activity after the operation.</abstract><pub>Trans Tech Publications Ltd</pub><doi>10.4028/www.scientific.net/KEM.361-363.1013</doi><tpages>4</tpages></addata></record> |
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| title | Application of Newly Developed Globular-Shaped Granules of β-Tricalcium Phosphate for Bone Substitute |
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