Designer emulsions using microfluidics

We describe new developments for the controlled fabrication of monodisperse emulsions using microfluidics. We use glass capillary devices to generate single, double, and higher order emulsions with exceptional precision. These emulsions can serve as ideal templates for generating well-defined partic...

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Bibliographic Details
Published in:Materials today (Kidlington, England) England), 2008-04, Vol.11 (4), p.18-27
Main Authors: Shah, Rhutesh K., Shum, Ho Cheung, Rowat, Amy C., Lee, Daeyeon, Agresti, Jeremy J., Utada, Andrew S., Chu, Liang-Yin, Kim, Jin-Woong, Fernandez-Nieves, Alberto, Martinez, Carlos J., Weitz, David A.
Format: Article
Language:English
Subjects:
Devices
Emulsions
Encapsulation
Genes
Glass
Microfluidics
Screening
Vesicles
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Summary:We describe new developments for the controlled fabrication of monodisperse emulsions using microfluidics. We use glass capillary devices to generate single, double, and higher order emulsions with exceptional precision. These emulsions can serve as ideal templates for generating well-defined particles and functional vesicles. Polydimethylsiloxane microfluidic devices are also used to generate picoliter-scale water-in-oil emulsions at rates as high as 10 000 drops per second. These emulsions have great potential as individual microvessels in high-throughput screening applications, where each drop serves to encapsulate single cells, genes, or reactants.
ISSN:1369-7021
1873-4103
DOI:10.1016/S1369-7021(08)70053-1