DNA Block Copolymer Micelles - A Combinatorial Tool for Cancer Nanotechnology

A novel micelle platform consisting of amphiphilic DNA block copolymers is introduced for chemotherapeutic drug delivery, allowing combinatorial testing of the drug carrier system. Oligodeoxynucleotide modified targeting units are “clicked” into the micelle corona by hybridization, allowing perfect...

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2008-03, Vol.20 (5), p.899-902
Main Authors: Alemdaroglu, F. E., Alemdaroglu, N. C., Langguth, P., Herrmann, A.
Format: Article
Language:English
Subjects:
Biomedical applications
Block copolymers
DNA
Drug delivery
Micelles
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Summary:A novel micelle platform consisting of amphiphilic DNA block copolymers is introduced for chemotherapeutic drug delivery, allowing combinatorial testing of the drug carrier system. Oligodeoxynucleotide modified targeting units are “clicked” into the micelle corona by hybridization, allowing perfect control of surface functionalities of the nanoparticle system. Cancer cells are efficiently killed when targeting units and chemotherapeutic act together within the DNA block copolymer aggregates.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.200700866