An antimicrobial TiO2 coating for reducing hospital-acquired infection

Titanium dioxide (TiO2) has been developed and applied extensively in the form of coatings, in particular for its unique properties such as non‐toxicity, high photocatalytic activity, and strong self‐cleaning ability. These coatings, which can be prepared via various processes, have not yet been pro...

Full description

Saved in:
Bibliographic Details
Published in:Journal of biomedical materials research. Part B, Applied biomaterials Applied biomaterials, 2008-04, Vol.85B (1), p.220-224
Main Authors: Chung, Chi-Jen, Lin, Hsin-I, Tsou, Hsi-Kai, Shi, Zhi-Yuan, He, Ju-Liang
Format: Article
Language:English
Subjects:
Animals
Anti-Infective Agents - chemistry
Anti-Infective Agents - pharmacology
Anti-Infective Agents - therapeutic use
antimicrobial
Coated Materials, Biocompatible - chemistry
Coated Materials, Biocompatible - therapeutic use
coating(s)
Cross Infection - drug therapy
Escherichia coli - drug effects
Humans
infection
Materials Testing
Microbial Sensitivity Tests
stainless steel
Staphylococcal Infections - drug therapy
Staphylococcus aureus - drug effects
Surface Properties
Titanium - chemistry
Titanium - pharmacology
Titanium - therapeutic use
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Titanium dioxide (TiO2) has been developed and applied extensively in the form of coatings, in particular for its unique properties such as non‐toxicity, high photocatalytic activity, and strong self‐cleaning ability. These coatings, which can be prepared via various processes, have not yet been proved to be antimicrobial. This research involves an arc ion plating method to produce TiO2 film on medical grade AISI 304 stainless steel. Antimicrobial efficacy of the deposits is expected due to the photocatalysis action of the anatase phase presented in the deposit. The performance of the coating is evaluated by a JIS Z2801:2000 industrial standard. Experimental results show that TiO2 film mainly consisting of anatase structure can be prepared with a high growth rate of 5 μm/h. Antimicrobial activity (R) of the deposited TiO2 film against Staphylococcus aureus and Escherichia coli was 3.0 and 2.5, respectively, far beyond the value designated in JIS standard. This provides an effective antimicrobial surface coating method for medical implements thereby reducing the risk of hospital‐acquired infections. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2008
ISSN:1552-4973
1552-4981
DOI:10.1002/jbm.b.30939