Recent advancements in biomaterials and medical devices, aiming to improve consistently the outcomes of therapeutic approaches within spine/cord injury

• Published in: Journal of Optoelectronics and Advanced Materials 2008-01, Vol.10 (1), p.18-28
• Main Authors: Onose, G, Ciurea, A V, Rizea, R E, Chendreanu, C, Anghelescu, A, Haras, M, Brehar, F, Padure, L
• Format: Article
• Language: English
• ISSN: 1454-4164

We emphasize some implantable 'smart', tissue engineering biomaterials and respectively, advanced devices, with important healing potential in spine and/or spinal cord injuries (SCI). There are two main types of such biomaterials: un-resorbable and resorbable, separate in two distinct/intricate cathegories: acellular and - more recent/complex-construct scaffolds (polymeric/gel-type, bioactive or/and self-assembling/ nano-processed). They serve as: continuity ((n)filling the gap')/holding (re)structures, intra-nevraxial neural (re)growth inhibitors' blockers, contains, guides or/and stimulators for neo-forming tissues, delivery vehicles for cells and growth/neuro-protective factors, host immune attack/reject reactions preventers, cell behavior controllers - including decrease of glial scar formation - or adjunct in bone grafting. Groundbreaking: molding 'biological ink' (of micro-inkjet cell aggregates) into 3-D shaped biodegradable polymer gels, to build organs from the ground up (including inside repair/regeneration). Related reliable trials are on going: they might, in the following about three years, eventually, show consistent improvements of SCI therapy outcomes.