Spontaneous formation of narrowly-distributed self-assembly from polyamidoamine dendron-poly(L-lysine) block copolymers through helix-coil transition of poly(L-lysine) block

The self-assembly of head-tail type block copolymers composed of polyamidoamine dendron head block and poly(L-lysine) (PLL) tail block was studied using a light scattering technique and transmission electron microscopy. A PLL tail block in a head-tail type block copolymer exhibits a coil-to-helix tr...

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Bibliographic Details
Published in:Journal of polymer science. Part A, Polymer chemistry Polymer chemistry, 2009-02, Vol.47 (4), p.1217-1223
Main Authors: Harada, Atsushi, Nakanishi, Kenichi, Ichimura, Shinichi, Kojima, Chie, Kono, Kenji
Format: Article
Language:English
Subjects:
Aminoacid polymers
Applied sciences
block copolymer
dendron
Exact sciences and technology
helix-coil transition
nanoparticle
Physicochemistry of polymers
polymersome
polypeptide
self-assembly
Synthetic biopolymers
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Summary:The self-assembly of head-tail type block copolymers composed of polyamidoamine dendron head block and poly(L-lysine) (PLL) tail block was studied using a light scattering technique and transmission electron microscopy. A PLL tail block in a head-tail type block copolymer exhibits a coil-to-helix transition as a result of the change in solvent quality from water to methanol. When the PLL tail block takes a helical conformation in high methanol content, the resulting head-tail type block copolymer has a defined three-dimensional structure like that of a protein molecule. Self-assemblies of such block copolymers having a totally fixed molecular shape spontaneously form polymersome-like self-assemblies with an extremely narrow size distribution through converging to a thermodynamically stable assembling state.
ISSN:0887-624X
1099-0518
DOI:10.1002/pola.23231