Nasal mucoadhesive drug delivery: Background, applications, trends and future perspectives

Nasal drug delivery has now been recognized as a very promising route for delivery of therapeutic compounds including biopharmaceuticals. It has been demonstrated that low absorption of drugs can be countered by using absorption enhancers or increasing the drug residence time in the nasal cavity, an...

Full description

Saved in:
Bibliographic Details
Published in:Advanced drug delivery reviews 2005-11, Vol.57 (11), p.1640-1665
Main Authors: Ugwoke, Michael I., Agu, Remigius U., Verbeke, Norbert, Kinget, Renaat
Format: Article
Language:English
Subjects:
Absorption enhancer
Adhesiveness
Administration, Intranasal
Animals
Biophysical Phenomena
Biophysics
Drug Delivery Systems - adverse effects
Humans
Microparticles
Microspheres
Mucoadhesion
Mucociliary clearance
Nasal absorption
Nasal drug delivery
Nasal Mucosa
Polymer
Tissue Adhesives
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Nasal drug delivery has now been recognized as a very promising route for delivery of therapeutic compounds including biopharmaceuticals. It has been demonstrated that low absorption of drugs can be countered by using absorption enhancers or increasing the drug residence time in the nasal cavity, and that some mucoadhesive polymers can serve both functions. This article reviews the background of nasal mucoadhesive drug delivery with special references to the biological and pharmaceutical considerations for nasal mucoadhesive drug administration. Applications of nasal mucoadhesives for the delivery of small organic molecules, antibiotics, proteins, vaccines and DNA are also discussed. Furthermore, new classes of functionalized mucoadhesive polymers, the characterization and safety aspects of nasal drug products as well as the opportunities presented by nasal drug delivery are extensively discussed.
ISSN:0169-409X
1872-8294
DOI:10.1016/j.addr.2005.07.009