Production of vaccines against leading biowarfare toxins can utilize DNA scientific technology

There are a significant number of different natural toxins that are potential biological warfare agents against which a vaccine is needed. DNA science has been a key to the development of potential vaccines against the top threat toxin and should contribute such effects for other toxin's vaccin...

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Bibliographic Details
Published in:Advanced drug delivery reviews 2005-06, Vol.57 (9), p.1415-1423
Main Author: Middlebrook, John L.
Format: Article
Language:English
Subjects:
Aerosol challenge
Animals
Antibody protection
Biological Warfare
Botulinum toxin
Botulinum Toxins - classification
Botulinum Toxins - immunology
Botulinum Toxins - toxicity
Humans
Immunization
Lethal Dose 50
Protein synthesis inhibition
Ricin
Ricin - toxicity
Technology, Pharmaceutical - trends
Toxins, Biological - classification
Toxins, Biological - immunology
Toxins, Biological - toxicity
Vaccines - biosynthesis
Vaccines, DNA
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Summary:There are a significant number of different natural toxins that are potential biological warfare agents against which a vaccine is needed. DNA science has been a key to the development of potential vaccines against the top threat toxin and should contribute such effects for other toxin's vaccines. Several different DNA technological scientific techniques have been used to accomplish the general goals of (1) cloning of the toxin or large toxin fragments, (2) altering the specific gene sequence to obtain high level expression of vaccine candidate production in alternate species (3) placement of the vaccine gene in very different presentation types of species.
ISSN:0169-409X
1872-8294
DOI:10.1016/j.addr.2005.01.016