Supramolecular organization of collagen and anti-cancer drugs

We have studied several biosystems comprising a fibrous protein, namely type 1 collagen (COL), which co-assembles with an anti-cancer drug, such as 5-fluorouracil (FLU) or doxorubicin (DOX), to form ordered films on glass or mica substrate, as visualized by atomic force microscopy. The anti-cancer d...

Full description

Saved in:
Bibliographic Details
Published in:Journal of Optoelectronics and Advanced Materials 2008-04, Vol.10 (4), p.961-964
Main Authors: Tomoaia, Gh, Tomoaia-Cotisel, M, Mocanu, A, Horovitz, O, Bobos, L D, Crisan, M, Petean, I
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We have studied several biosystems comprising a fibrous protein, namely type 1 collagen (COL), which co-assembles with an anti-cancer drug, such as 5-fluorouracil (FLU) or doxorubicin (DOX), to form ordered films on glass or mica substrate, as visualized by atomic force microscopy. The anti-cancer drugs appear to lead to supramolecular collagen structures, with a remarkable nanoscale order, that mimics natural protein assemblies. Direct incorporation of such small molecules into the collagen assemblies represents a step toward rational design of nanostructured materials for a wide range of applications in synthetic biology and medicine, including the design of new drug delivery systems.
ISSN:1454-4164