Cyclodextrins in transdermal and rectal delivery

Transdermal and rectal routes of drugs are very important as a useful supplement of oral routes and the direct exposing method of drugs when the systemic and local effects are required. The widespread use of parent cyclodextrins (CDs) and chemically modified CD derivatives (CD derivatives) for in-vi...

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Bibliographic Details
Published in:Advanced drug delivery reviews 1999-03, Vol.36 (1), p.81-99
Main Authors: Matsuda, Hajime, Arima, Hidetoshi
Format: Article
Language:English
Subjects:
Complexation
Cyclodextrin
Derivatives
Drug absorption
Drug delivery
Drug infusion
Drug products
Drug release
Local irritation
Mechanical permeability
Permeability
Rectum
Skin
Stability constant
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Summary:Transdermal and rectal routes of drugs are very important as a useful supplement of oral routes and the direct exposing method of drugs when the systemic and local effects are required. The widespread use of parent cyclodextrins (CDs) and chemically modified CD derivatives (CD derivatives) for in-vitro and in-vivo dermal and rectal drug delivery have been evaluated. In addition, the application of hydrophilic CD derivatives to cosmetics have been progressing. In this article, the current status of parent CDs and CD derivatives in the transdermal and rectal delivery of conventional low molecular weight agents are reviewed.
ISSN:0169-409X
1872-8294
DOI:10.1016/S0169-409X(98)00056-8