IκB, NF-κB Regulation Model: Simulation Analysis of Small Number of Molecules

The regulation of I kappa B, NF- kappa B is of foremost interest in biology as the transcription factor NF- kappa B has multiple target genes. We have modeled a previously published model by Hoffmann et al. (2002) of I kappa B, NF- kappa B mathematically as discrete reaction systems. We have used st...

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Bibliographic Details
Published in:EURASIP journal on bioinformatics & systems biology 2007, Vol.2007, p.1-10
Main Authors: Sarkar, Anamika, Meila, Marina, Franza, Robert B.
Format: Article
Language:English
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Summary:The regulation of I kappa B, NF- kappa B is of foremost interest in biology as the transcription factor NF- kappa B has multiple target genes. We have modeled a previously published model by Hoffmann et al. (2002) of I kappa B, NF- kappa B mathematically as discrete reaction systems. We have used stochastic algorithm to compare the results when there are large and small numbers of molecules available in a finite volume for each protein. Our results for small number of molecules show that with continuous presence of stimulation, nuclear NF- kappa B oscillates continuously in every individual cell rather than damping, which was observed in cell population results. This characteristic of the system is missed when averaged behavior is studied.
ISSN:1687-4145
1687-4153
DOI:10.1155/2007/25250