In Vivo Performance of an Injectable Biphasic Calcium Phosphate Bone Filler

An hydrated putty was prepared by mixing submicron particles, rounded particles and granules of Biphasic Calcium Phosphate (BCP) ceramics composed of HA and β-TCP phases. The material filled entirely critical sized defects in the femoral epiphysis of NZW rabbits. After 3, 6 and 12 weeks, histology r...

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Bibliographic Details
Published in:Key engineering materials 2009-01, Vol.396-398, p.583-586
Main Authors: Layrolle, Pierre, Aguado, Eric, Goyenvalle, Eric, Daculsi, Guy, Moreau, Françoise, Baroth, Serge
Format: Article
Language:English
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Summary:An hydrated putty was prepared by mixing submicron particles, rounded particles and granules of Biphasic Calcium Phosphate (BCP) ceramics composed of HA and β-TCP phases. The material filled entirely critical sized defects in the femoral epiphysis of NZW rabbits. After 3, 6 and 12 weeks, histology revealed that submicron particles were rapidly degraded by multinucleated TRAP-positive cells. This osteoclastic resorption stimulated bone ingrowth while the large BCP particles served as scaffold supporting bone healing by osteoconduction.
ISSN:1013-9826
1662-9795
1662-9795
DOI:10.4028/www.scientific.net/KEM.396-398.583