The comparisons of prognostic indexes using data mining techniques and Cox regression analysis in the breast cancer data

The purpose of this study is to determine new prognostic indexes for the differentiation of subgroups of breast cancer patients with the techniques of decision tree algorithms (C&RT, CHAID, QUEST, ID3, C4.5 and C5.0) and Cox regression analysis for disease-free survival (DFS) in breast cancer pa...

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Bibliographic Details
Published in:Expert systems with applications 2009-05, Vol.36 (4), p.8247-8254
Main Authors: Ture, Mevlut, Tokatli, Fusun, Kurt Omurlu, Imran
Format: Article
Language:English
Subjects:
Breast cancer
C&RT
C4.5
C5.0
CHAID
Cox regression
Decision tree
Disease-free survival
ID3
Kaplan–Meier
QUEST
Random survival forests
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Summary:The purpose of this study is to determine new prognostic indexes for the differentiation of subgroups of breast cancer patients with the techniques of decision tree algorithms (C&RT, CHAID, QUEST, ID3, C4.5 and C5.0) and Cox regression analysis for disease-free survival (DFS) in breast cancer patients. A retrospective analysis was performed in 381 breast cancer patients diagnosed. Age, menopausal status, age of menarche, family history of cancer, histologic tumor type, quadrant of tumor, tumor size, estrogen and progesterone receptor status, histologic and nuclear grading, axillary nodal status, pericapsular involvement of lymph nodes, lymphovascular and perineural invasion, adjuvant radiotherapy, chemotherapy and hormonal therapy were assessed. Based on these prognostic factors, new prognostic indexes for C&RT, CHAID, QUEST, ID3, C4.5 and C5.0 and Cox regression were obtained. Prognostic indexes showed a good degree of classification, which demonstrates that an improvement seems possible using standard risk factors. We obtained that C4.5 has a better performance than C&RT, CHAID, QUEST, ID3, C5.0 and Cox regression to determine risk groups using Random Survival Forests (RSF).
ISSN:0957-4174
1873-6793
DOI:10.1016/j.eswa.2008.10.014