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A generalized model of mutation–selection balance with applications to aging
A probability model is presented for the dynamics of mutation–selection balance in a haploid infinite-population infinite-sites setting sufficiently general to cover mutation-driven changes in full age-specific demographic schedules. The model accommodates epistatic as well as additive selective cos...
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Published in: | Advances in applied mathematics 2005-07, Vol.35 (1), p.16-33 |
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Main Authors: | , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | A probability model is presented for the dynamics of mutation–selection balance in a haploid infinite-population infinite-sites setting sufficiently general to cover mutation-driven changes in full age-specific demographic schedules. The model accommodates epistatic as well as additive selective costs. Closed form characterizations are obtained for solutions in finite time, along with proofs of convergence to stationary distributions and a proof of the uniqueness of solutions in a restricted case. Examples are given of applications to the biodemography of aging. |
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ISSN: | 0196-8858 1090-2074 |
DOI: | 10.1016/j.aam.2004.09.003 |