Ultrathin Coatings with Change in Reactivity over Time Enable Functional In Vitro Networks Of Insect Neurons

It's just not cricket! A novel coating system that enables covalent attachment of biomolecules in a nonfouling environment without use of additional chemical crosslinkers is presented. Concanavalin A is patterned on the coatings to direct cell adhesion and growth of neurons from the cricket Gry...

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2008-07, Vol.20 (14), p.2751-2755
Main Authors: Reska, Anna, Gasteier, Peter, Schulte, Petra, Moeller, Martin, Offenhäusser, Andreas, Groll, Juergen
Format: Article
Language:English
Subjects:
Attachment
biocompatible materials
biosensors
Coatings
Covalence
Crickets
hydrogels
In vitro testing
Insects
microcontact printing
Networks
Neurons
thin films
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Summary:It's just not cricket! A novel coating system that enables covalent attachment of biomolecules in a nonfouling environment without use of additional chemical crosslinkers is presented. Concanavalin A is patterned on the coatings to direct cell adhesion and growth of neurons from the cricket Gryllus bimaculatus and generate functional, patterned in vitro insect neuronal networks for the first time.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.200800270