Artificial Disc: Chemical and Biomechanical Analysis

Degeneration of intervertebral discs is the most common cause of back pain. The first phase of this degenerative process involves the nucleus pulposus. A rapid recovery of this structure can prevent further degradation of the annulus fibrosus. Guar Gum is an hydrophilic polysaccharide extracted from...

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Bibliographic Details
Published in:Macromolecular symposia 2008-06, Vol.266 (1), p.74-80
Main Authors: Mercuri, D, Leone, G, Barbucci, R, Favaloro, R, Facchini, A, Signori, F, Bronco, S, Ciardelli, F
Format: Article
Language:English
Subjects:
annulus fibrosus
Applied sciences
Biological and medical sciences
Crosslinking
Degradation
Disks
Dispersions
Exact sciences and technology
Extraction plants
guar gum
hydrogel
Hydrogels
intervertebral disc degeneration
Intervertebral discs
Medical sciences
Natural polymers
Nuclei
nucleus pulposus
Physicochemistry of polymers
Starch and polysaccharides
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Technology. Biomaterials. Equipments
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Summary:Degeneration of intervertebral discs is the most common cause of back pain. The first phase of this degenerative process involves the nucleus pulposus. A rapid recovery of this structure can prevent further degradation of the annulus fibrosus. Guar Gum is an hydrophilic polysaccharide extracted from the seed endosperm of a plant. Through a cross-linking procedure a Guar hydrogel was synthesized. The Guar hydrogel could be injected by a syringe and it is a good candidate as a nucleus pulposus substitute. For the preparation of the artificial fibrosus annulus, commercially available polymer materials are tuned to achieve suitable mechanical properties. To achieve this peculiar behaviour, the main strategy investigated is the dispersion of hollow polymer micro spheres in a thermoplastic polymer matrix. Processing conditions and particle content are finely tuned to get the target mechanical behaviour.
ISSN:1022-1360
1521-3900
DOI:10.1002/masy.200850614