Synthesis and characterization of biodegradable pH-sensitive hydrogels based on poly(ɛ-caprolactone), methacrylic acid, and poly(ethylene glycol)

In this work, a novel biodegradable pH-sensitive hydrogel based on poly(ɛ-caprolactone) (PCL), methoxpoly(ethylene glycol) (MPEG) and methacrylic acid (MAA) was prepared by UV-initiated free radical polymerization. The resulting macromonomers and hydrogels were characterized by FTIR and/or 1H NMR. S...

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Bibliographic Details
Published in:Polymer degradation and stability 2009-04, Vol.94 (4), p.730-737
Main Authors: Wang, Ke, Fu, Shao Zhi, Gu, Ying Chun, Xu, Xu, Dong, Peng Wei, Guo, Gang, Zhao, Xia, Wei, Yu Quan, Qian, Zhi Yong
Format: Article
Language:English
Subjects:
Applied sciences
Biodegradable
Degradation
Dynamic swelling/deswelling
Exact sciences and technology
Organic polymers
pH sensitive
Physicochemistry of polymers
Properties and characterization
Solution and gel properties
Water absorption
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Summary:In this work, a novel biodegradable pH-sensitive hydrogel based on poly(ɛ-caprolactone) (PCL), methoxpoly(ethylene glycol) (MPEG) and methacrylic acid (MAA) was prepared by UV-initiated free radical polymerization. The resulting macromonomers and hydrogels were characterized by FTIR and/or 1H NMR. Swelling behaviour and pH sensitivity of the hydrogels were studied in detail. With increase in pH of aqueous medium from 1.2 to 7.2, swelling ratio of the hydrogels increased accordingly. The hydrolytic degradation behaviour was also investigated. The prepared biodegradable pH-sensitive hydrogel based on PCL, MPEG, and MAA might have great potential application in smart drug delivery system.
ISSN:0141-3910
1873-2321
DOI:10.1016/j.polymdegradstab.2008.12.013