Synthesis and primary biological evaluation of ReN-NEMPTDD

A new nitrido-Re complex, ReN-NEMPTDD, was synthesized through a modified method in high yield. This complex was stable in vitro. The biodistribution in normal mice showed that this ReN complex accumulated in the liver and was eliminated quickly from almost all organs. VX2 carcinoma was grown in the...

Full description

Saved in:
Bibliographic Details
Published in:Journal of radioanalytical and nuclear chemistry 2008-08, Vol.277 (2), p.365-369
Main Authors: Wang, Guan-Quan, Zhang, Ji, Luo, Shun-Zhong, Wang, Na, Wei, Hong-Yuan, Wang, Wen-Jin, Yang, Yu-Qing, Liu, Guo-Ping, Yu, Xiao-Qi
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A new nitrido-Re complex, ReN-NEMPTDD, was synthesized through a modified method in high yield. This complex was stable in vitro. The biodistribution in normal mice showed that this ReN complex accumulated in the liver and was eliminated quickly from almost all organs. VX2 carcinoma was grown in the livers of rabbits. Transcatheter arterial embolization (TAE) was performed using ReN-NEMPTDD/lipiodol solution. The SPECT images showed that the lipiodol solution could be concentrated in the tumor for about 12 hours. These results indicated that ReN-NEMPTDD/lipiodol could be a potential radiopharmaceutical for liver cancer.
ISSN:0236-5731
DOI:10.1007/s10967-007-7033-2