Cardiovascular Disease Risk among Atomic Bomb Survivors Exposed In Utero, 1978–2003

Tatsukawa, Y., Nakashima, E., Yamada, M., Funamoto, S., Hida, A., Akahoshi, M., Sakata, R., Ross, N. P., Kasagi, F., Fujiwara, S. and Shore, R. E. Cardiovascular Disease Risk among Atomic Bomb Survivors Exposed In Utero, 1978–2003. Radiat. Res. 170, 269–274 (2008). Given the well-documented associat...

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Published in:Radiation research 2008-09, Vol.170 (3), p.269-274
Main Authors: Tatsukawa, Yoshimi, Nakashima, Eiji, Yamada, Michiko, Funamoto, Sachiyo, Hida, Ayumi, Akahoshi, Masazumi, Sakata, Ritsu, Ross, Norman P., Kasagi, Fumiyoshi, Fujiwara, Saeko, Shore, Roy E.
Format: Article
Language:English
Subjects:
Atomic bombs
Cardiovascular diseases
Cardiovascular Diseases - epidemiology
Childhood
Disease risk
Dosimetry
Epidemiology
Female
Humans
Hypertension
Japan - epidemiology
Male
Middle Aged
Nuclear Warfare - statistics & numerical data
Patient assessment
Pregnancy
Prenatal Exposure Delayed Effects - epidemiology
Prevalence
Radiation dosage
Radiation Injuries - epidemiology
Radiotherapy
Regular s
Risk Assessment - methods
Risk Factors
Survivors - statistics & numerical data
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creator Tatsukawa, Yoshimi
Nakashima, Eiji
Yamada, Michiko
Funamoto, Sachiyo
Hida, Ayumi
Akahoshi, Masazumi
Sakata, Ritsu
Ross, Norman P.
Kasagi, Fumiyoshi
Fujiwara, Saeko
Shore, Roy E.
description Tatsukawa, Y., Nakashima, E., Yamada, M., Funamoto, S., Hida, A., Akahoshi, M., Sakata, R., Ross, N. P., Kasagi, F., Fujiwara, S. and Shore, R. E. Cardiovascular Disease Risk among Atomic Bomb Survivors Exposed In Utero, 1978–2003. Radiat. Res. 170, 269–274 (2008). Given the well-documented association of in utero radiation exposure with childhood cancer and developmental impairments, the possibility of effects on adult onset diseases is an important issue. The objectives of the present study were to examine the effects of atomic bomb radiation dose on the incidence of hypertension, hypercholesterolemia and cardiovascular disease (myocardial infarction and stroke) among survivors exposed in utero and to compare their risk estimates with those of survivors exposed in childhood (
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There were no significant radiation dose effects for any diseases in the entire in utero-exposed cohort or in trimester-of-exposure subgroups, though there was a suggestion of an increased risk when fatal and nonfatal cardiovascular disease cases were combined. Positive radiation dose effects were found for hypertension and cardiovascular disease in the childhood-exposure cohort, but there were no statistically significant differences in the relative risks when we compared the two cohorts. 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subjects Atomic bombs
Cardiovascular diseases
Cardiovascular Diseases - epidemiology
Childhood
Disease risk
Dosimetry
Epidemiology
Female
Humans
Hypertension
Japan - epidemiology
Male
Middle Aged
Nuclear Warfare - statistics & numerical data
Patient assessment
Pregnancy
Prenatal Exposure Delayed Effects - epidemiology
Prevalence
Radiation dosage
Radiation Injuries - epidemiology
Radiotherapy
Regular s
Risk Assessment - methods
Risk Factors
Survivors - statistics & numerical data
title Cardiovascular Disease Risk among Atomic Bomb Survivors Exposed In Utero, 1978–2003
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