Field-Effect Nanoparticle-Based Glucose Sensor on a Chip: Amplification Effect of Coimmobilized Redox Species

A capacitive EIS (electrolyte‐insulator‐semiconductor) structure was modified with gold nanoparticles together with glucose oxidase and used as field‐effect‐based glucose biosensor using the constant capacitance mode. Co‐immobilization of ferrocene redox species resulted in a two‐fold increase of th...

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Bibliographic Details
Published in:Electroanalysis (New York, N.Y.) N.Y.), 2008-08, Vol.20 (16), p.1748-1753
Main Authors: Gun, Jenny, Schöning, Michael J., Abouzar, Maryam H., Poghossian, Arshak, Katz, Evgeny
Format: Article
Language:English
Subjects:
Capacitive EIS (electrolyte-insulator-semiconductor) structure
Field-effect sensor
Functionalized nanoparticle
Glucose oxidase
Glucose sensor
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Summary:A capacitive EIS (electrolyte‐insulator‐semiconductor) structure was modified with gold nanoparticles together with glucose oxidase and used as field‐effect‐based glucose biosensor using the constant capacitance mode. Co‐immobilization of ferrocene redox species resulted in a two‐fold increase of the biosensor sensitivity. The effect was explained by the hydrogen peroxide‐mediated oxidation of ferrocene resulting in a pool of charged species at the interface increasing the sensor response towards glucose. The studied approach was suggested as a general means to amplify signals from Si chip‐based field‐effect enzyme biosensors.
ISSN:1040-0397
1521-4109
DOI:10.1002/elan.200804255