In vitro behavior of bioactive phosphate glass–ceramics from the system P2O5–Na2O–CaO containing titania

• Published in: Ceramics international 2009-04, Vol.35 (3), p.1195-1204
• Main Authors: ElBatal, H.A., Khalil, E.M.A., Hamdy, Y.M.
• Format: Article
• Language: English
• ISSN: 0272-8842
• DOI: 10.1016/j.ceramint.2008.06.004

Soda lime phosphate bioglass-ceramics with small additions of TiO2 were prepared in the metaphosphate and pyrophosphate region, using an appropriate two-step heat treatment of controlled crystallisation defined by DTA. Identification and quantification of crystalline phases precipitated from the soda lime phosphate glasses were performed using XRD. Calcium pyrophosphate (beta-Ca2P2O7), sodium metaphosphate (NaPO3), calcium metaphosphate (beta-Ca(PO3)2), sodium pyrophosphate (Na4P2O7), sodium calcium phosphate (Na4Ca(PO3)6) and sodium titanium phosphate (Na5Ti(PO4)3) phases were detected in the prepared glass-ceramics. The degradation of the prepared glass-ceramics was carried out for different periods of time in simulated body fluid at 37 C using granules in the range 0.300-0.600 mm. The released ions were estimated by AAS and the surface textures were measured by SEM. Investigation of in-vitro bioactivity of the prepared glass-ceramics showed that no apatite layer was formed on the surface of the samples and the dominant phase remaining on the surface was beta-Ca2P2O7, which is known for its bioactivity.