Interaction of BSA protein with copper evaluated by electrochemical impedance spectroscopy and quartz crystal microbalance

The interaction of bovine serum albumin (BSA) protein with copper in phosphate buffer solution has been studied by a combination of electrochemical impedance spectroscopy (EIS) close to the open circuit potential, with simultaneous monitoring by the electrochemical quartz crystal microbalance (EQCM)...

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Bibliographic Details
Published in:Electrochimica acta 2008-10, Vol.53 (25), p.7460-7466
Main Authors: Pinto, Edilson M., Soares, David M., Brett, Christopher M.A.
Format: Article
Language:English
Subjects:
Adsorption
Bovine serum albumin
Chemistry
Copper
Electrochemical impedance spectroscopy
Electrochemical quartz crystal microbalance
Electrochemistry
Exact sciences and technology
General and physical chemistry
Study of interfaces
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Summary:The interaction of bovine serum albumin (BSA) protein with copper in phosphate buffer solution has been studied by a combination of electrochemical impedance spectroscopy (EIS) close to the open circuit potential, with simultaneous monitoring by the electrochemical quartz crystal microbalance (EQCM), in order to throw light on BSA adsorption. Copper films were electroplated onto gold quartz crystals and mounted in the EQCM. Experiments were conducted in the presence and absence of dissolved oxygen and of BSA and the results show the influence of O 2 on the protein/metal interaction and also show specific interactions between BSA and copper. The good reproducibility obtained in these experiments suggests future application to other systems and which should lead to a better understanding of the use of such types of protein as corrosion inhibitors.
ISSN:0013-4686
1873-3859
DOI:10.1016/j.electacta.2008.01.096