Immune-enhancing activities of low molecular weight b-glucan depolymerized by gamma irradiation

b-glucans are structural cell wall polymers of many microorganisms and cereals which possess immunomodulatory properties and have been used in the food, cosmetic and medical industry. In our previous study, b-glucan was depolymerized by gamma irradiation and leads to improve the solubility and visco...

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Published in:Radiation physics and chemistry (Oxford, England : 1993) England : 1993), 2009-08, Vol.78 (7-8), p.433-436
Main Authors: Sung, Nak-Yun, Byun, Eui-Hong, Kwon, Sun-Kyu, Song, Beom-Seok, Choi, Jong-Il, Kim, Jae-Hun, Byun, Myung-Woo, Yoo, Young-Choon, Kim, Mee-Ree, Lee, Ju-Woon
Format: Article
Language:English
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Summary:b-glucans are structural cell wall polymers of many microorganisms and cereals which possess immunomodulatory properties and have been used in the food, cosmetic and medical industry. In our previous study, b-glucan was depolymerized by gamma irradiation and leads to improve the solubility and viscosity. This study was carried out to evaluate the functional properties, mainly immune-enhancing activities of low molecular weight b-glucan fragmented by gamma irradiation. The results showed that RAW 264.7 macrophage cell stimulation activities of irradiated b-glucan were higher than that of non-irradiated b-glucan. In addition, the oral administration of gamma-irradiated b-glucan significantly increased the proliferation and cytokine (IFN-g and IL-2) release of spleen and Peyer's patch cells compared with non-irradiated b- glucan. In conclusion, gamma irradiation could be used as an effective method for the production of depolymerized b-glucan improved functional property such as immunomodulatory activity.
ISSN:0969-806X
DOI:10.1016/j.radphyschem.2009.03.022