Chitosan-poly(acrylic acid) complex modified paramagnetic Fe(3)O(4) nanoparticles for camptothecin loading and release

The stable superparamagnetic colloidal suspension of chitosan-poly(acrylic acid) (CS-PAA)/Fe(3)O(4) nanoparticles was synthesized by graft copolymerization AA on the surface of CS stabilized Fe(3)O(4) nanoparticles. The size, size distribution, structure, and magnetic properties of the resultant CS-...

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Bibliographic Details
Published in:Journal of materials research 2009-07, Vol.24 (7), p.2307-2315
Main Authors: Zhu, Aiping, Luo, Xiadan, Dai, Sheng
Format: Article
Language:English
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Summary:The stable superparamagnetic colloidal suspension of chitosan-poly(acrylic acid) (CS-PAA)/Fe(3)O(4) nanoparticles was synthesized by graft copolymerization AA on the surface of CS stabilized Fe(3)O(4) nanoparticles. The size, size distribution, structure, and magnetic properties of the resultant CS-PAA/Fe(3)O(4) nanoparticles were characterized by field-emission scanning electron microscopy (FE-SEM), transmission electron microscope (TEM), dynamic light scattering, Fourier transform infrared spectroscopy, x-ray diffraction, and vibrating sample magnetometry (VSM). FE-SEM and TEM showed the spherelike morphology of CS-PAA/Fe(3)O(4) nanoparticles with their diameter ranging from 15 to 60 nm. VSM measurements indicated that CS-PAA/Fe(3)O(4) nanoparticles preserved the superparamagnetism. CS-PAA complex was proved to be a good stabilizer to prepare the well-dispersed suspension of superparamagnetic Fe(3)O(4) nanoparticles. The stabilizing mechanisms were attributed to the electrostatic repulsion and steric hindrance. The controlled release of entrapped camptothecin from these magnetic nanoparticles was studied and the release mechanism was analyzed.
ISSN:0884-2914
DOI:10.1557/JMR.2009.0284