Radioprotection by DMSO in nitrogen-saturated mammalian cells exposed to helium ion beams

The contribution of OH radical-mediated indirect action by particle beams under hypoxic irradiation condition was investigated by using a radical scavenger. V79 cells were irradiated with 150 MeV/nucleon helium ions at an LET of 2.2 keV/μm in the presence or absence of DMSO, and their colony surviva...

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Bibliographic Details
Published in:Radiation physics and chemistry (Oxford, England : 1993) England : 1993), 2009-12, Vol.78 (12), p.1175-1178
Main Authors: Hirayama, Ryoichi, Matsumoto, Yoshitaka, Kase, Yuki, Noguchi, Miho, Ando, Koichi, Ito, Atsushi, Okayasu, Ryuichi, Furusawa, Yoshiya
Format: Article
Language:English
Subjects:
Cell killing
Helium ion beam
HIMAC
Hypoxia
Indirect action
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Summary:The contribution of OH radical-mediated indirect action by particle beams under hypoxic irradiation condition was investigated by using a radical scavenger. V79 cells were irradiated with 150 MeV/nucleon helium ions at an LET of 2.2 keV/μm in the presence or absence of DMSO, and their colony survivals were determined. The contribution of indirect action to cell killing under hypoxic condition was estimated to be 52±9%. We conclude that OH radical-mediated indirect action still has a half in total contribution on cell killing under hypoxic condition.
ISSN:0969-806X
1879-0895
DOI:10.1016/j.radphyschem.2009.07.006