Radioprotection by DMSO in nitrogen-saturated mammalian cells exposed to helium ion beams

The contribution of OH radical-mediated indirect action by particle beams under hypoxic irradiation condition was investigated by using a radical scavenger. V79 cells were irradiated with 150 MeV/nucleon helium ions at an LET of 2.2 keV/μm in the presence or absence of DMSO, and their colony surviva...

Full description

Saved in:
Bibliographic Details
Published in:Radiation physics and chemistry (Oxford, England : 1993) England : 1993), 2009-12, Vol.78 (12), p.1175-1178
Main Authors: Hirayama, Ryoichi, Matsumoto, Yoshitaka, Kase, Yuki, Noguchi, Miho, Ando, Koichi, Ito, Atsushi, Okayasu, Ryuichi, Furusawa, Yoshiya
Format: Article
Language:English
Subjects:
Cell killing
Helium ion beam
HIMAC
Hypoxia
Indirect action
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c462t-68c6df4bcece7533be99cfe514487708a3b42c3e08e2400affc50cfcfce0f5863
cites cdi_FETCH-LOGICAL-c462t-68c6df4bcece7533be99cfe514487708a3b42c3e08e2400affc50cfcfce0f5863
container_end_page 1178
container_issue 12
container_start_page 1175
container_title Radiation physics and chemistry (Oxford, England : 1993)
container_volume 78
creator Hirayama, Ryoichi
Matsumoto, Yoshitaka
Kase, Yuki
Noguchi, Miho
Ando, Koichi
Ito, Atsushi
Okayasu, Ryuichi
Furusawa, Yoshiya
description The contribution of OH radical-mediated indirect action by particle beams under hypoxic irradiation condition was investigated by using a radical scavenger. V79 cells were irradiated with 150 MeV/nucleon helium ions at an LET of 2.2 keV/μm in the presence or absence of DMSO, and their colony survivals were determined. The contribution of indirect action to cell killing under hypoxic condition was estimated to be 52±9%. We conclude that OH radical-mediated indirect action still has a half in total contribution on cell killing under hypoxic condition.
doi_str_mv 10.1016/j.radphyschem.2009.07.006
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_34916786</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0969806X0900320X</els_id><sourcerecordid>34916786</sourcerecordid><originalsourceid>FETCH-LOGICAL-c462t-68c6df4bcece7533be99cfe514487708a3b42c3e08e2400affc50cfcfce0f5863</originalsourceid><addsrcrecordid>eNqNkEtPwzAQhC0EEqXwH8yFW8Lm5dhHVJ5SUSUeEpwsx9lQV0lcbAfRf0_acuCI9rDSama08xFynkCcQMIuV7FT9Xq58XqJXZwCiBjKGIAdkEnCSxEBF8UhmYBgIuLA3o7JifcrACh5kU3I-5OqjV07G1AHY3tabej14_OCmp72Jjj7gX3kVRicCljTTnWdao3qqca29RS_19aP92DpElszdHSXgarzp-SoUa3Hs989Ja-3Ny-z-2i-uHuYXc0jnbM0RIxrVjd5pVFjWWRZhULoBoskz3lZAldZlac6Q-CY5gCqaXQBuhkHoSk4y6bkYp87lvgc0AfZGb_9TvVoBy-zXCSs3AnFXqid9d5hI9fOdMptZAJyC1Ou5B-YcgtTQilHmKN3tvfi2OTLoJNeG-w11saN4GRtzT9SfgD-y4ZH</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>34916786</pqid></control><display><type>article</type><title>Radioprotection by DMSO in nitrogen-saturated mammalian cells exposed to helium ion beams</title><source>Elsevier</source><creator>Hirayama, Ryoichi ; Matsumoto, Yoshitaka ; Kase, Yuki ; Noguchi, Miho ; Ando, Koichi ; Ito, Atsushi ; Okayasu, Ryuichi ; Furusawa, Yoshiya</creator><creatorcontrib>Hirayama, Ryoichi ; Matsumoto, Yoshitaka ; Kase, Yuki ; Noguchi, Miho ; Ando, Koichi ; Ito, Atsushi ; Okayasu, Ryuichi ; Furusawa, Yoshiya</creatorcontrib><description>The contribution of OH radical-mediated indirect action by particle beams under hypoxic irradiation condition was investigated by using a radical scavenger. V79 cells were irradiated with 150 MeV/nucleon helium ions at an LET of 2.2 keV/μm in the presence or absence of DMSO, and their colony survivals were determined. The contribution of indirect action to cell killing under hypoxic condition was estimated to be 52±9%. We conclude that OH radical-mediated indirect action still has a half in total contribution on cell killing under hypoxic condition.</description><identifier>ISSN: 0969-806X</identifier><identifier>EISSN: 1879-0895</identifier><identifier>DOI: 10.1016/j.radphyschem.2009.07.006</identifier><language>eng</language><publisher>Elsevier Ltd</publisher><subject>Cell killing ; Helium ion beam ; HIMAC ; Hypoxia ; Indirect action</subject><ispartof>Radiation physics and chemistry (Oxford, England : 1993), 2009-12, Vol.78 (12), p.1175-1178</ispartof><rights>2009 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c462t-68c6df4bcece7533be99cfe514487708a3b42c3e08e2400affc50cfcfce0f5863</citedby><cites>FETCH-LOGICAL-c462t-68c6df4bcece7533be99cfe514487708a3b42c3e08e2400affc50cfcfce0f5863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Hirayama, Ryoichi</creatorcontrib><creatorcontrib>Matsumoto, Yoshitaka</creatorcontrib><creatorcontrib>Kase, Yuki</creatorcontrib><creatorcontrib>Noguchi, Miho</creatorcontrib><creatorcontrib>Ando, Koichi</creatorcontrib><creatorcontrib>Ito, Atsushi</creatorcontrib><creatorcontrib>Okayasu, Ryuichi</creatorcontrib><creatorcontrib>Furusawa, Yoshiya</creatorcontrib><title>Radioprotection by DMSO in nitrogen-saturated mammalian cells exposed to helium ion beams</title><title>Radiation physics and chemistry (Oxford, England : 1993)</title><description>The contribution of OH radical-mediated indirect action by particle beams under hypoxic irradiation condition was investigated by using a radical scavenger. V79 cells were irradiated with 150 MeV/nucleon helium ions at an LET of 2.2 keV/μm in the presence or absence of DMSO, and their colony survivals were determined. The contribution of indirect action to cell killing under hypoxic condition was estimated to be 52±9%. We conclude that OH radical-mediated indirect action still has a half in total contribution on cell killing under hypoxic condition.</description><subject>Cell killing</subject><subject>Helium ion beam</subject><subject>HIMAC</subject><subject>Hypoxia</subject><subject>Indirect action</subject><issn>0969-806X</issn><issn>1879-0895</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNqNkEtPwzAQhC0EEqXwH8yFW8Lm5dhHVJ5SUSUeEpwsx9lQV0lcbAfRf0_acuCI9rDSama08xFynkCcQMIuV7FT9Xq58XqJXZwCiBjKGIAdkEnCSxEBF8UhmYBgIuLA3o7JifcrACh5kU3I-5OqjV07G1AHY3tabej14_OCmp72Jjj7gX3kVRicCljTTnWdao3qqca29RS_19aP92DpElszdHSXgarzp-SoUa3Hs989Ja-3Ny-z-2i-uHuYXc0jnbM0RIxrVjd5pVFjWWRZhULoBoskz3lZAldZlac6Q-CY5gCqaXQBuhkHoSk4y6bkYp87lvgc0AfZGb_9TvVoBy-zXCSs3AnFXqid9d5hI9fOdMptZAJyC1Ou5B-YcgtTQilHmKN3tvfi2OTLoJNeG-w11saN4GRtzT9SfgD-y4ZH</recordid><startdate>20091201</startdate><enddate>20091201</enddate><creator>Hirayama, Ryoichi</creator><creator>Matsumoto, Yoshitaka</creator><creator>Kase, Yuki</creator><creator>Noguchi, Miho</creator><creator>Ando, Koichi</creator><creator>Ito, Atsushi</creator><creator>Okayasu, Ryuichi</creator><creator>Furusawa, Yoshiya</creator><general>Elsevier Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20091201</creationdate><title>Radioprotection by DMSO in nitrogen-saturated mammalian cells exposed to helium ion beams</title><author>Hirayama, Ryoichi ; Matsumoto, Yoshitaka ; Kase, Yuki ; Noguchi, Miho ; Ando, Koichi ; Ito, Atsushi ; Okayasu, Ryuichi ; Furusawa, Yoshiya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-68c6df4bcece7533be99cfe514487708a3b42c3e08e2400affc50cfcfce0f5863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Cell killing</topic><topic>Helium ion beam</topic><topic>HIMAC</topic><topic>Hypoxia</topic><topic>Indirect action</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hirayama, Ryoichi</creatorcontrib><creatorcontrib>Matsumoto, Yoshitaka</creatorcontrib><creatorcontrib>Kase, Yuki</creatorcontrib><creatorcontrib>Noguchi, Miho</creatorcontrib><creatorcontrib>Ando, Koichi</creatorcontrib><creatorcontrib>Ito, Atsushi</creatorcontrib><creatorcontrib>Okayasu, Ryuichi</creatorcontrib><creatorcontrib>Furusawa, Yoshiya</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Radiation physics and chemistry (Oxford, England : 1993)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hirayama, Ryoichi</au><au>Matsumoto, Yoshitaka</au><au>Kase, Yuki</au><au>Noguchi, Miho</au><au>Ando, Koichi</au><au>Ito, Atsushi</au><au>Okayasu, Ryuichi</au><au>Furusawa, Yoshiya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Radioprotection by DMSO in nitrogen-saturated mammalian cells exposed to helium ion beams</atitle><jtitle>Radiation physics and chemistry (Oxford, England : 1993)</jtitle><date>2009-12-01</date><risdate>2009</risdate><volume>78</volume><issue>12</issue><spage>1175</spage><epage>1178</epage><pages>1175-1178</pages><issn>0969-806X</issn><eissn>1879-0895</eissn><abstract>The contribution of OH radical-mediated indirect action by particle beams under hypoxic irradiation condition was investigated by using a radical scavenger. V79 cells were irradiated with 150 MeV/nucleon helium ions at an LET of 2.2 keV/μm in the presence or absence of DMSO, and their colony survivals were determined. The contribution of indirect action to cell killing under hypoxic condition was estimated to be 52±9%. We conclude that OH radical-mediated indirect action still has a half in total contribution on cell killing under hypoxic condition.</abstract><pub>Elsevier Ltd</pub><doi>10.1016/j.radphyschem.2009.07.006</doi><tpages>4</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0969-806X
ispartof Radiation physics and chemistry (Oxford, England : 1993), 2009-12, Vol.78 (12), p.1175-1178
issn 0969-806X
1879-0895
language eng
recordid cdi_proquest_miscellaneous_34916786
source Elsevier
subjects Cell killing
Helium ion beam
HIMAC
Hypoxia
Indirect action
title Radioprotection by DMSO in nitrogen-saturated mammalian cells exposed to helium ion beams
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T15%3A43%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Radioprotection%20by%20DMSO%20in%20nitrogen-saturated%20mammalian%20cells%20exposed%20to%20helium%20ion%20beams&rft.jtitle=Radiation%20physics%20and%20chemistry%20(Oxford,%20England%20:%201993)&rft.au=Hirayama,%20Ryoichi&rft.date=2009-12-01&rft.volume=78&rft.issue=12&rft.spage=1175&rft.epage=1178&rft.pages=1175-1178&rft.issn=0969-806X&rft.eissn=1879-0895&rft_id=info:doi/10.1016/j.radphyschem.2009.07.006&rft_dat=%3Cproquest_cross%3E34916786%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c462t-68c6df4bcece7533be99cfe514487708a3b42c3e08e2400affc50cfcfce0f5863%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=34916786&rft_id=info:pmid/&rfr_iscdi=true