Life threatening intracerebral hemorrhage with isometheptene mucate, dichlorophenazine and acetaminophen combination therapy

Abstract A 45 year old female with no stroke risk factors suffered a massive intracerebral hemorrhage (ICH) after ingesting Midrin – a combination of isometheptene mucate, dichlorophenazine and acetaminophen. Neuroimaging revealed no evidence of structural disease or underlying vasculopathy. This is...

Full description

Saved in:
Bibliographic Details
Published in:Journal of forensic and legal medicine 2009-11, Vol.16 (8), p.489-491
Main Author: Johnston, James C., MD JD
Format: Article
Language:English
Subjects:
Acetaminophen - administration & dosage
Acetaminophen - adverse effects
Analgesics - administration & dosage
Analgesics - adverse effects
Antipyrine - administration & dosage
Antipyrine - adverse effects
Antipyrine - analogs & derivatives
Cerebral Hemorrhage - chemically induced
Chloral Hydrate - administration & dosage
Chloral Hydrate - adverse effects
Chloral Hydrate - analogs & derivatives
Drug Combinations
Female
Headache
Humans
Intracerebral hemorrhage
Isometheptene
Methylamines - administration & dosage
Methylamines - adverse effects
Middle Aged
Midrin
Migraine
Pathology
Suicide
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract A 45 year old female with no stroke risk factors suffered a massive intracerebral hemorrhage (ICH) after ingesting Midrin – a combination of isometheptene mucate, dichlorophenazine and acetaminophen. Neuroimaging revealed no evidence of structural disease or underlying vasculopathy. This is the first reported case of isometheptene induced ICH in the absence of underlying cerebrovascular disease. Physicians must be aware of the potential for this complication, and inquire about the use of isometheptene in unexplained cerebral hemorrhages. Neurological communities in countries with nonprescription isometheptene should discourage unsupervised or excessive use of the drug.
ISSN:1752-928X
1878-7487
DOI:10.1016/j.jflm.2009.07.006