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Life threatening intracerebral hemorrhage with isometheptene mucate, dichlorophenazine and acetaminophen combination therapy
Abstract A 45 year old female with no stroke risk factors suffered a massive intracerebral hemorrhage (ICH) after ingesting Midrin – a combination of isometheptene mucate, dichlorophenazine and acetaminophen. Neuroimaging revealed no evidence of structural disease or underlying vasculopathy. This is...
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| Published in: | Journal of forensic and legal medicine 2009-11, Vol.16 (8), p.489-491 |
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| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c472t-578e1ca4469d2d1f19ac3c208b0581289915b11b10e241da9ffd451399e4e9443 |
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| cites | cdi_FETCH-LOGICAL-c472t-578e1ca4469d2d1f19ac3c208b0581289915b11b10e241da9ffd451399e4e9443 |
| container_end_page | 491 |
| container_issue | 8 |
| container_start_page | 489 |
| container_title | Journal of forensic and legal medicine |
| container_volume | 16 |
| creator | Johnston, James C., MD JD |
| description | Abstract A 45 year old female with no stroke risk factors suffered a massive intracerebral hemorrhage (ICH) after ingesting Midrin – a combination of isometheptene mucate, dichlorophenazine and acetaminophen. Neuroimaging revealed no evidence of structural disease or underlying vasculopathy. This is the first reported case of isometheptene induced ICH in the absence of underlying cerebrovascular disease. Physicians must be aware of the potential for this complication, and inquire about the use of isometheptene in unexplained cerebral hemorrhages. Neurological communities in countries with nonprescription isometheptene should discourage unsupervised or excessive use of the drug. |
| doi_str_mv | 10.1016/j.jflm.2009.07.006 |
| format | article |
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Neuroimaging revealed no evidence of structural disease or underlying vasculopathy. This is the first reported case of isometheptene induced ICH in the absence of underlying cerebrovascular disease. Physicians must be aware of the potential for this complication, and inquire about the use of isometheptene in unexplained cerebral hemorrhages. Neurological communities in countries with nonprescription isometheptene should discourage unsupervised or excessive use of the drug.</description><identifier>ISSN: 1752-928X</identifier><identifier>EISSN: 1878-7487</identifier><identifier>DOI: 10.1016/j.jflm.2009.07.006</identifier><identifier>PMID: 19782324</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject><![CDATA[Acetaminophen - administration & dosage ; Acetaminophen - adverse effects ; Analgesics - administration & dosage ; Analgesics - adverse effects ; Antipyrine - administration & dosage ; Antipyrine - adverse effects ; Antipyrine - analogs & derivatives ; Cerebral Hemorrhage - chemically induced ; Chloral Hydrate - administration & dosage ; Chloral Hydrate - adverse effects ; Chloral Hydrate - analogs & derivatives ; Drug Combinations ; Female ; Headache ; Humans ; Intracerebral hemorrhage ; Isometheptene ; Methylamines - administration & dosage ; Methylamines - adverse effects ; Middle Aged ; Midrin ; Migraine ; Pathology ; Suicide]]></subject><ispartof>Journal of forensic and legal medicine, 2009-11, Vol.16 (8), p.489-491</ispartof><rights>Elsevier Ltd and Faculty of Forensic and Legal Medicine</rights><rights>2009 Elsevier Ltd and Faculty of Forensic and Legal Medicine</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-578e1ca4469d2d1f19ac3c208b0581289915b11b10e241da9ffd451399e4e9443</citedby><cites>FETCH-LOGICAL-c472t-578e1ca4469d2d1f19ac3c208b0581289915b11b10e241da9ffd451399e4e9443</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19782324$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Johnston, James C., MD JD</creatorcontrib><title>Life threatening intracerebral hemorrhage with isometheptene mucate, dichlorophenazine and acetaminophen combination therapy</title><title>Journal of forensic and legal medicine</title><addtitle>J Forensic Leg Med</addtitle><description>Abstract A 45 year old female with no stroke risk factors suffered a massive intracerebral hemorrhage (ICH) after ingesting Midrin – a combination of isometheptene mucate, dichlorophenazine and acetaminophen. Neuroimaging revealed no evidence of structural disease or underlying vasculopathy. This is the first reported case of isometheptene induced ICH in the absence of underlying cerebrovascular disease. Physicians must be aware of the potential for this complication, and inquire about the use of isometheptene in unexplained cerebral hemorrhages. Neurological communities in countries with nonprescription isometheptene should discourage unsupervised or excessive use of the drug.</description><subject>Acetaminophen - administration & dosage</subject><subject>Acetaminophen - adverse effects</subject><subject>Analgesics - administration & dosage</subject><subject>Analgesics - adverse effects</subject><subject>Antipyrine - administration & dosage</subject><subject>Antipyrine - adverse effects</subject><subject>Antipyrine - analogs & derivatives</subject><subject>Cerebral Hemorrhage - chemically induced</subject><subject>Chloral Hydrate - administration & dosage</subject><subject>Chloral Hydrate - adverse effects</subject><subject>Chloral Hydrate - analogs & derivatives</subject><subject>Drug Combinations</subject><subject>Female</subject><subject>Headache</subject><subject>Humans</subject><subject>Intracerebral hemorrhage</subject><subject>Isometheptene</subject><subject>Methylamines - administration & dosage</subject><subject>Methylamines - adverse effects</subject><subject>Middle Aged</subject><subject>Midrin</subject><subject>Migraine</subject><subject>Pathology</subject><subject>Suicide</subject><issn>1752-928X</issn><issn>1878-7487</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNqFkk-r1TAQxYsovufTL-BCunJlayZNbxIQ4fHwH1xwoYK7kKbT11zbpCapcsUPb-q9ILjQ1YTJ75yBOVMUj4HUQGD3_FAfhmmuKSGyJrwmZHenuATBRcWZ4Hfzm7e0klR8vigexHggpGWUt_eLC5Bc0Iayy-Ln3g5YpjGgTuisuy2tS0EbDNgFPZUjzj6EUd9i-d2msbTRz5hGXDKN5byaLHtW9taMkw9-GdHpHzb_aNeX2SXp2brf7dL4ubNOJ-tdnodBL8eHxb1BTxEfnetV8en1q483b6v9-zfvbq73lWGcpqrlAsFoxnaypz0MILVpDCWiI60AKqSEtgPogCBl0Gs5DD1roZESGUrGmqvi6cl3Cf7rijGp2UaD06Qd-jWqhkkhmWj_C1IA0e7aDaQn0AQfY8BBLcHOOhwVELWFow5qC0dt4SjCVQ4ni56c3dduxv6P5JxGBl6cAMzL-GYxqGgsOoO9DWiS6r39t__Lv-Rmss4aPX3BI8aDX4PLa1agIlVEfdjOY7sOIgkBoLz5BcwjuEg</recordid><startdate>20091101</startdate><enddate>20091101</enddate><creator>Johnston, James C., MD JD</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope></search><sort><creationdate>20091101</creationdate><title>Life threatening intracerebral hemorrhage with isometheptene mucate, dichlorophenazine and acetaminophen combination therapy</title><author>Johnston, James C., MD JD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-578e1ca4469d2d1f19ac3c208b0581289915b11b10e241da9ffd451399e4e9443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Acetaminophen - administration & dosage</topic><topic>Acetaminophen - adverse effects</topic><topic>Analgesics - administration & dosage</topic><topic>Analgesics - adverse effects</topic><topic>Antipyrine - administration & dosage</topic><topic>Antipyrine - adverse effects</topic><topic>Antipyrine - analogs & derivatives</topic><topic>Cerebral Hemorrhage - chemically induced</topic><topic>Chloral Hydrate - administration & dosage</topic><topic>Chloral Hydrate - adverse effects</topic><topic>Chloral Hydrate - analogs & derivatives</topic><topic>Drug Combinations</topic><topic>Female</topic><topic>Headache</topic><topic>Humans</topic><topic>Intracerebral hemorrhage</topic><topic>Isometheptene</topic><topic>Methylamines - administration & dosage</topic><topic>Methylamines - adverse effects</topic><topic>Middle Aged</topic><topic>Midrin</topic><topic>Migraine</topic><topic>Pathology</topic><topic>Suicide</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Johnston, James C., MD JD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Journal of forensic and legal medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Johnston, James C., MD JD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Life threatening intracerebral hemorrhage with isometheptene mucate, dichlorophenazine and acetaminophen combination therapy</atitle><jtitle>Journal of forensic and legal medicine</jtitle><addtitle>J Forensic Leg Med</addtitle><date>2009-11-01</date><risdate>2009</risdate><volume>16</volume><issue>8</issue><spage>489</spage><epage>491</epage><pages>489-491</pages><issn>1752-928X</issn><eissn>1878-7487</eissn><abstract>Abstract A 45 year old female with no stroke risk factors suffered a massive intracerebral hemorrhage (ICH) after ingesting Midrin – a combination of isometheptene mucate, dichlorophenazine and acetaminophen. Neuroimaging revealed no evidence of structural disease or underlying vasculopathy. This is the first reported case of isometheptene induced ICH in the absence of underlying cerebrovascular disease. Physicians must be aware of the potential for this complication, and inquire about the use of isometheptene in unexplained cerebral hemorrhages. Neurological communities in countries with nonprescription isometheptene should discourage unsupervised or excessive use of the drug.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>19782324</pmid><doi>10.1016/j.jflm.2009.07.006</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1752-928X |
| ispartof | Journal of forensic and legal medicine, 2009-11, Vol.16 (8), p.489-491 |
| issn | 1752-928X 1878-7487 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_34989485 |
| source | ScienceDirect Journals |
| subjects | Acetaminophen - administration & dosage Acetaminophen - adverse effects Analgesics - administration & dosage Analgesics - adverse effects Antipyrine - administration & dosage Antipyrine - adverse effects Antipyrine - analogs & derivatives Cerebral Hemorrhage - chemically induced Chloral Hydrate - administration & dosage Chloral Hydrate - adverse effects Chloral Hydrate - analogs & derivatives Drug Combinations Female Headache Humans Intracerebral hemorrhage Isometheptene Methylamines - administration & dosage Methylamines - adverse effects Middle Aged Midrin Migraine Pathology Suicide |
| title | Life threatening intracerebral hemorrhage with isometheptene mucate, dichlorophenazine and acetaminophen combination therapy |
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