PEGylated Calcium Phosphate Nanocomposites as Smart Environment‐Sensitive Carriers for siRNA Delivery

A novel inorganic–organic hybrid nanocomposite is formed in situ using a simple and straightforward method. Conjugate of short interfering RNA (siRNA) duplex with poly(ethylene glycol) via a disulfide linkage (PEG–SS–siRNA) is demonstrated to regulate the crystal growth of calcium phosphate (CaP), y...

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2009-09, Vol.21 (34), p.3520-3525
Main Authors: Zhang, Mingzhen, Ishii, Atsushi, Nishiyama, Nobuhiro, Matsumoto, Satoru, Ishii, Takehiko, Yamasaki, Yuichi, Kataoka, Kazunori
Format: Article
Language:English
Subjects:
Calcium phosphate
Gene delivery
Hybrid micelles
RNA interference
siRNA
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Summary:A novel inorganic–organic hybrid nanocomposite is formed in situ using a simple and straightforward method. Conjugate of short interfering RNA (siRNA) duplex with poly(ethylene glycol) via a disulfide linkage (PEG–SS–siRNA) is demonstrated to regulate the crystal growth of calcium phosphate (CaP), yielding a monodispersed nanocomposite. The resultant nanocomposite can be utilized as nanocarriers for siRNA delivery.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.200800448