Clathrin light chains contain brain-specific insertion sequences and a region of homology with intermediate filaments

The primary structures of four bovine clathrin light chains have been determined. Light chains LCa and LCb are homologous proteins encoded by different genes. In the brain the messenger RNA from these genes undergoes differential splicing to yield proteins having centrally inserted brain-specific se...

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Bibliographic Details
Published in:Nature (London) 1987-03, Vol.326 (6109), p.154-159
Main Authors: Jackson, A P, Seow, H F, Holmes, N, Drickamer, K, Parham, P
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Base Sequence
Brain
Brain - physiology
Cattle
Cellular biology
clathrin
Clathrin - genetics
Intermediate Filament Proteins
Medical disorders
Medical research
Protein Conformation
Proteins
RNA Splicing
RNA, Messenger - genetics
Solubility
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Summary:The primary structures of four bovine clathrin light chains have been determined. Light chains LCa and LCb are homologous proteins encoded by different genes. In the brain the messenger RNA from these genes undergoes differential splicing to yield proteins having centrally inserted brain-specific sequences. A potentially alpha-helical region of the clathrin light chains shows homology with intermediate filament proteins.
ISSN:0028-0836
1476-4687
DOI:10.1038/326154a0