Control of synaptic strength by glial TNF[alpha]

Activity-dependent modulation of synaptic efficacy in the brain contributes to neural circuit development and experience-dependent plasticity. The authors show in a study that a protein produced by glia, tumor necrosis factor alpha, enhances synaptic efficacy by increasing surface expression of AMPA...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2002-03, Vol.295 (5563), p.2282-2285
Main Authors: Beattie, Eric C, Stellwagen, David, Morishita, Wade, Bresnahan, Jacqueline C
Format: Article
Language:English
Subjects:
Brain
Neural circuitry
Neurology
Neurons
Physiological aspects
Proteins
Synapses
Tumor necrosis factor
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Summary:Activity-dependent modulation of synaptic efficacy in the brain contributes to neural circuit development and experience-dependent plasticity. The authors show in a study that a protein produced by glia, tumor necrosis factor alpha, enhances synaptic efficacy by increasing surface expression of AMPA receptors.
ISSN:0036-8075
1095-9203