Activation of Muscarinic Potassium Currents by ATPgammaS in Atrial Cells

A study of the intracellular perfusion of atrial myocytes with adenosine 5'-(gamma-thio) triphosphate (ATPgammaS) discovered that cytosolic application of ATPgammaS can also lead to G-protein activation, thus implying that experiments with ATPgammaS must be interpreted with caution. References.

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1988-10, Vol.242 (4877), p.443-443
Main Authors: Otero, Angela S, Breitwieser, Gerda E, Szabo, Gabor
Format: Article
Language:English
Subjects:
Biochemistry
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Summary:A study of the intracellular perfusion of atrial myocytes with adenosine 5'-(gamma-thio) triphosphate (ATPgammaS) discovered that cytosolic application of ATPgammaS can also lead to G-protein activation, thus implying that experiments with ATPgammaS must be interpreted with caution. References.
ISSN:0036-8075
1095-9203