Drug-Resistant Salmonella in the United States: An Epidemiologic Perspective

Salmonellosis poses a health problem of large proportions in the United States. Annually, it accounts for more than 40,000 reported cases, 500 deaths, and financial costs well in excess of $50 million. Antimicrobial resistance is increasing in Salmonella strains, a finding that has important public...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1986-11, Vol.234 (4779), p.964-969
Main Authors: Cohen, Mitchell L., Tauxe, Robert V.
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Antibiotic resistance
Antimicrobials
Bacteriology
Biological and medical sciences
Case studies
Chloramphenicol - pharmacology
Disease
Disease Outbreaks - epidemiology
Disease resistance
Dosage
Drug resistance in microorganisms
Drug Resistance, Microbial
Drugs
Epidemiology
Fundamental and applied biological sciences. Psychology
Gastroenteritis - etiology
Humans
Infections
Medical research
Meningitis - drug therapy
Microbial drug resistance
Microbiology
Salmonella
Salmonella - drug effects
Salmonella Food Poisoning
Salmonella infections
Salmonella Infections - epidemiology
Salmonella Infections, Animal - transmission
Salmonellosis
Sepsis - drug therapy
United States
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Summary:Salmonellosis poses a health problem of large proportions in the United States. Annually, it accounts for more than 40,000 reported cases, 500 deaths, and financial costs well in excess of $50 million. Antimicrobial resistance is increasing in Salmonella strains, a finding that has important public health implications. Although the chain of transmission of the bacteria is often complex, combined epidemiologic and laboratory studies with the use of new methods in molecular biology make it possible to trace antimicrobial-resistant salmonellae to their primary source--foods of animal origin. These studies suggest that the antimicrobial drugs to which food animals are exposed provide selective pressure that leads to the appearance and persistence of resistant strains.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.3535069