Gene Expression Needs a Break to Unwind before Carrying On

The molecular events that change a quiescent gene within compacted chromatin into one actively transcribing RNA are not yet clear. Unexpectedly, enzymes that create and repair DNA breaks seem to be necessary.

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2006-06, Vol.312 (5781), p.1752-1753
Main Authors: Haince, Jean-François, Rouleau, Michèle, Poirier, Guy G.
Format: Article
Language:English
Subjects:
Chromatin
DNA
DNA damage
DNA repair
Enzymes
Gene expression
Gene expression regulation
Genes
Genomics
Histones
Nuclear receptors
Perspectives
Ribonucleic acid
RNA
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Description
Summary:The molecular events that change a quiescent gene within compacted chromatin into one actively transcribing RNA are not yet clear. Unexpectedly, enzymes that create and repair DNA breaks seem to be necessary.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1129808