Mapping the Antigenic and Genetic Evolution of Influenza Virus

The antigenic evolution of influenza A (H3N2) virus was quantified and visualized from its introduction into humans in 1968 to 2003. Although there was remarkable correspondence between antigenic and genetic evolution, significant differences were observed: Antigenic evolution was more punctuated th...

Full description

Saved in:
Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2004-07, Vol.305 (5682), p.371-376
Main Authors: Smith, Derek J., Lapedes, Alan S., de Jong, Jan C., Bestebroer, Theo M., Rimmelzwaan, Guus F., Albert D. M. E. Osterhaus, Ron A. M. Fouchier
Format: Article
Language:English
Subjects:
Amino Acid Substitution
Antigenic Variation
Biological and medical sciences
Communicable Diseases
Epidemiology
Evolution
Evolution, Molecular
Evolutionary genetics
Fundamental and applied biological sciences. Psychology
Genes, Viral
Genetic aspects
Genetic Drift
Genetic mapping
Genetic Variation
Genetics
H3N2 subtype influenza A virus
Hemagglutination Inhibition Tests
Hemagglutinins, Viral - chemistry
Hemagglutinins, Viral - genetics
Hemagglutinins, Viral - immunology
Human genetics
Humans
Influenza
Influenza A virus
Influenza A virus - genetics
Influenza A virus - immunology
Influenza, Human - epidemiology
Influenza, Human - virology
Medical genetics
Microbiology
Molecular Sequence Data
Multidimensional Scaling
Mutagenesis, Site-Directed
Mutation
Observation
Pathogens
Seasons
Vaccination
Vaccines
Virology
Virology - methods
Viruses
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The antigenic evolution of influenza A (H3N2) virus was quantified and visualized from its introduction into humans in 1968 to 2003. Although there was remarkable correspondence between antigenic and genetic evolution, significant differences were observed: Antigenic evolution was more punctuated than genetic evolution, and genetic change sometimes had a disproportionately large antigenic effect. The method readily allows monitoring of antigenic differences among vaccine and circulating strains and thus estimation of the effects of vaccination. Further, this approach offers a route to predicting the relative success of emerging strains, which could be achieved by quantifying the combined effects of population level immune escape and viral fitness on strain evolution.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1097211