Biotin-, Pyrene-, and GRGDS-Functionalized Polymers and Nanogels via ATRP and End Group Modification

Functionality, one of the key attributes of atom transfer radical polymerization (ATRP), was utilized for the synthesis of well‐controlled polymers functionalized with biotin, pyrene, and peptides. Hydroxy‐functionalized poly(oligo(ethylene oxide) monomethyl ether methacrylate) (HO‐POEOMA) was prepa...

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Bibliographic Details
Published in:Macromolecular chemistry and physics 2008-11, Vol.209 (21), p.2179-2193
Main Authors: Siegwart, Daniel J., Oh, Jung Kwon, Gao, Haifeng, Bencherif, Sidi A., Perineau, Fabien, Bohaty, Andrew K., Hollinger, Jeffrey O., Matyjaszewski, Krzysztof
Format: Article
Language:English
Subjects:
AGET
Applied sciences
atom transfer radical polymerisation
bioconjugate
biomolecules
click chemistry
Exact sciences and technology
functionality
inverse miniemulsion
Organic polymers
overline {DP}
Physicochemistry of polymers
Polymers with particular structures
Preparation, kinetics, thermodynamics, mechanism and catalysts
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Summary:Functionality, one of the key attributes of atom transfer radical polymerization (ATRP), was utilized for the synthesis of well‐controlled polymers functionalized with biotin, pyrene, and peptides. Hydroxy‐functionalized poly(oligo(ethylene oxide) monomethyl ether methacrylate) (HO‐POEOMA) was prepared by AGET ATRP of OEOMA initiated by 2‐hydroxyethyl 2‐bromoisobutyrate in water or in inverse miniemulsion of water/cyclohexane at ambient temperature. HO‐POEOMA was then further functionalized with biotin, pyrene, and GRGDS peptide. In addition, ATRP and click chemistry offered an efficient route for the synthesis of telechelic di‐biotin polymers. These general methods can be applied to the formation of different functional materials conjugated with proteins, dyes, nucleic acids, and drugs.
ISSN:1022-1352
1521-3935
DOI:10.1002/macp.200800337