Smart nanoprobes for ultrasensitive detection of breast cancer via magnetic resonance imaging

Antibody-conjugated hydrophilic magnetic nanocrystals for use as smart nanoprobes were developed for ultrasensitive detection of breast cancer via magnetic resonance (MR) imaging. MnFe(2)O(4) nanocrystals (MNCs) for use as MR imaging contrast agents were synthesized by thermal decomposition to take...

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Published in:Nanotechnology 2008-12, Vol.19 (48), p.485101-485101 (9)
Main Authors: Lee, Jaemin, Yang, Jaemoon, Seo, Sung-Baek, Ko, Hyun-Ju, Suh, Jin-Suck, Huh, Yong-Min, Haam, Seungjoo
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cited_by cdi_FETCH-LOGICAL-c421t-b4e0332296c7b6a3e5ff4aee9a80ec1c27477e264482f68c33961ba78beb785a3
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container_end_page 485101 (9)
container_issue 48
container_start_page 485101
container_title Nanotechnology
container_volume 19
creator Lee, Jaemin
Yang, Jaemoon
Seo, Sung-Baek
Ko, Hyun-Ju
Suh, Jin-Suck
Huh, Yong-Min
Haam, Seungjoo
description Antibody-conjugated hydrophilic magnetic nanocrystals for use as smart nanoprobes were developed for ultrasensitive detection of breast cancer via magnetic resonance (MR) imaging. MnFe(2)O(4) nanocrystals (MNCs) for use as MR imaging contrast agents were synthesized by thermal decomposition to take advantage of their MR signal enhancement effect. The MNC surfaces were then modified with amphiphilic tri-block copolymers (dicarboxy poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)), not only allowing the MNCs to transfer from the organic to the aqueous phase, but also increasing the colloidal stability of the MNCs by masking poly(ethylene glycol). The physicochemical properties of the synthesized hydrophilic magnetic nanocrystals (HMNCs) were fully investigated. Trastuzumab (TZ), a monoclonal antibody against human epidermal growth factor receptor (HER2/neu), was further conjugated on the surface of HMNCs to specifically target HER2/neu over-expressed breast cancer cells. MR imaging analysis of target cells treated with TZ-conjugated HMNCs (TZ-HMNCs) clearly demonstrated their potential as high-performance nanoprobes for selective imaging.
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title Smart nanoprobes for ultrasensitive detection of breast cancer via magnetic resonance imaging
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