Application of core–shell PEGylated CdS/Cd(OH) 2 quantum dots as biolabels of Trypanosoma cruzi parasites

Semiconductor quantum dots are a promising class of materials in the labeling of biological systems. In the present study we show the marking pattern of Trypanosoma cruzi ( T. cruzi) live parasites using PEGylated CdS/Cd(OH) 2 fluorescent nanocrystals. The analysis obtained by confocal fluorescence...

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Bibliographic Details
Published in:Applied surface science 2008-11, Vol.255 (3), p.728-730
Main Authors: Chaves, C.R., Fontes, A., Farias, P.M.A., Santos, B.S., de Menezes, F.D., Ferreira, R.C., Cesar, C.L., Galembeck, A., Figueiredo, R.C.B.Q.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biotechnology
Fluorescence
Fundamental and applied biological sciences. Psychology
General aspects, investigation technics, apparatus
Methods. Procedures. Technologies
Others
Parasites
Quantum dots
Spectroscopic and microscopic techniques in biophysics and medical physics
Tissues, organs and organisms biophysics
Trypanosoma cruzi
Various methods and equipments
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Summary:Semiconductor quantum dots are a promising class of materials in the labeling of biological systems. In the present study we show the marking pattern of Trypanosoma cruzi ( T. cruzi) live parasites using PEGylated CdS/Cd(OH) 2 fluorescent nanocrystals. The analysis obtained by confocal fluorescence microscopy and transmission electron microscopy indicates that only the endocytic paths of parasites were labeled. The parasites were alive after the incubation with the CdS/Cd(OH) 2–PEG suspension. Labeling the T. cruzi with quantum dots can help to better understand the endocytosis process and also the cellular differentiation.
ISSN:0169-4332
1873-5584
DOI:10.1016/j.apsusc.2008.07.035