Near‐Infrared Mesoporous Silica Nanoparticles for Optical Imaging: Characterization and In Vivo Biodistribution

The characterization of near‐infrared (NIR) mesoporous silica nanoparticles (MSN) suitable for in vivo optical imaging with high efficiency is presented. Trimethylammonium groups modified MSN (MSN‐TA) with the average size of 50–100 nm was synthesized with incorporation of the TA groups into the fra...

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Bibliographic Details
Published in:Advanced functional materials 2009-01, Vol.19 (2), p.215-222
Main Authors: Lee, Chia‐Hung, Cheng, Shih‐Hsun, Wang, Yu‐Jing, Chen, Yu‐Ching, Chen, Nai‐Tzu, Souris, Jeffrey, Chen, Chin‐Tu, Mou, Chung‐Yuan, Yang, Chung‐Shi, Lo, Leu‐Wei
Format: Article
Language:English
Subjects:
Biodistribution
Indocyanine green
Mesoporous silica nanoparticles
Near‐infrared
Optical imaging
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Summary:The characterization of near‐infrared (NIR) mesoporous silica nanoparticles (MSN) suitable for in vivo optical imaging with high efficiency is presented. Trimethylammonium groups modified MSN (MSN‐TA) with the average size of 50–100 nm was synthesized with incorporation of the TA groups into the framework of MSN. It was further adsorbed with indocyanine green (ICG) by electrostatic attraction to render MSN‐TA‐ICG as an efficient NIR contrast agent for in vivo optical imaging. The studies in stability of MSN‐TA‐ICG against pH indicated the bonding is stable over the range from acidic to physiological pH. The in vivo biodistribution of MSN‐TA‐ICG in anesthetized rat demonstrated a rather strong and stable fluorescence of MSN‐TA‐ICG that prominent in the organ of liver. Transmission electron microscopy (TEM) imaging and elemental analysis of silicon further manifested the physical and quantitative residences of MSN‐TA‐ICG in major organs. This is the first report of MSN functionalized with NIR‐ICG capable of optical imaging in vivo. Indocyanine green (ICG)‐functionalized mesoporous silica nanoparticles (MSNs) for in vivo near‐infrared optical imaging with high efficiency are presented for the first time. The in vivo biodistribution of MSNs‐ICG in anesthetized rat demonstrates a rather strong and stable fluorescence. TEM images and elemental analysis of the tissue after administration further supported the physical and quantitative residences of MSN‐TA‐ICG in different major organs.
ISSN:1616-301X
1616-3028
DOI:10.1002/adfm.200800753